Accelerated cTBS on Metabolic Dysfunction in People With Schizophrenia

Central South University40 enrolled

Overview

cTBS is a promising novel intervention, which has strong potential on moderating disease syndrome. However, the most effective pattern of the cTBS is still under debate. Therefore, the investigators designed this randomized controlled clinical trial to evaluate the efficacy and safety of accelerated cTBS, with 1800 stimulation per session, on intervention to metabolic side effects in individuals with schizophrenia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Schizophrenia Metabolic Disturbance Eating Behavior Transcranial Magnetic Stimulation

Interventions

accelerated theta burst stimulationDEVICE

cTBS was administered at 80% of each participant's M1 area in a burst-firing pattern (3 pulses at 50 Hz) with a repetition frequency of 5 Hz (200 ms intervals). During each session, participants received 1800 pulses (120 s).

Sham stimulationDEVICE

Similar process with the accelerated theta burst stimulation with the coil 90 degrees tilted to the surface of the scalp, which could produce identical sound and vibration while avoiding real magnetic stimulation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with schizophrenia in accordance with DSM-5 * BMI over 24 * Accepting antipsychotics stable treatment for more then 2 months Exclusion Criteria: * Diagnosed with other mental disease in accordance with DSM-5 * Comorbid with other severe physiological disease * Used antipsychotic, antidepressants, mood stabilizer, or other psychoactive substances before * Drug or alcohol abuse * Pregnant or lactating Contraindication to rTMS

Locations (1)

Second Xiangya Hospital Central South University

Changsha, Hunan, China

RECRUITING