This research will investigate the effect of oral probiotic supplements on renal function, uremic toxins inflammatory response, nutrition status, gastrointestinal symptoms, and QoL with Chronic kidney disease.
Chronic kidney disease (CKD) with gut microbiota was different from a normal person. Some gut microbiota produces short-chain fatty acids or induces functional enzymes beneficial to patients. On the other hand, some gut microbiota may also metabolize amino acids into p-cresol and indole which were leading to the accumulation of urinary toxins and damage to the kidney. This research will investigate the effect of oral probiotic supplements on renal function, uremic toxins, inflammatory response, nutrition status, gastrointestinal symptoms, and QoL with CKD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
80
Placebo (Microcrystalline α-cellulose) supplement with a Plant-Dominant Low-Protein Diet
Probiotics(Pediococcus acidilactici GKA4) supplement with a Plant-Dominant Low-Protein Diet
Taiwan
Taichung, ROC, Taiwan
Estimated glomerular filtration rate (eGFR) measurement
The eGFR level is a maker for kidney function
Time frame: Baseline to 24 week
Blood Urea Nitrogen (BUN) levels
Blood Urea Nitrogen
Time frame: Baseline to 24 week
Electrolytes Analysis
The concentration of electrolytes analysis in the subject's blood samples
Time frame: Baseline to 24 week
Uremic toxins assay
The concentration of p-cresol sulfate level, indoxyl sulfates level, and trimethylamine N-oxide level (TMAO) in the subjects' blood samples
Time frame: Baseline to 24 week
Sugar test
The concentration of fasting sugar and HbA1C in the subjects' blood samples
Time frame: Baseline to 24 week
Nutrition status
The concentration of albumin,TIBC,TFS and uric acid in the subjects' blood samples
Time frame: Baseline to 24 week
Inflammation makers
The concentration of inflammation makers in the subjects' blood samples
Time frame: Baseline to 24 week
Liver function
The concentration of ALT and AST in the subjects' blood samples
Time frame: Baseline to 24 week
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Lipid analysis
The concentration of total cholesterol , triglyceride , HDL-cholesterol and LDL-cholesterol in the subjects' blood samples
Time frame: Baseline to 24 week
The quality of life
Health-related quality of life was measured by 5-level EQ-5D questionnaire
Time frame: Baseline to 24 week
Complete Blood Count (CBC) Test
The concentration of CBC test in the subject's blood samples
Time frame: Baseline to 24 week
Urine Analysis
Urine specimen collection will be evaluate such as urine routine ,bacteria, protein and MCP-1.
Time frame: Baseline to 24 week
24-hour Dietary recall
There will be collected by food models or a photography atlas to estimate portion size.
Time frame: Baseline to 24 week
Safety and compliance
Gastrointestinal symptoms measured by questionnaire
Time frame: Baseline to 24 week
Grip strength levels
Hand grip strength was measured by grip strength device
Time frame: Baseline to 24 week