Caloric restriction may alter the response to chemotherapy induced stress response and enhance its antitumor effect. This study intends to use an intermitted caloric restriction protocol with alternate days before the chemotherapy administration to enhance the cytotoxic effect generated by standard treatment of cancer.
This pilot trial will provide preliminary evidence that 1) intermittent caloric restriction and a plant-based diet is feasible in cancer patients; 2) intermittent caloric restriction and a plant-based diet can be safely combined with standard chemotherapy; and 3) intermittent caloric restriction and a plant-based diet may reduce the side effects but increase the antitumor effects of standard chemotherapy.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Using dietary interventions as an adjuvant tool may represent an effective step toward advancing the treatment options of cancer. Dietary modifications can impact the growth and proliferation of tumors via multiple mechanisms
University at Buffalo / Great Lakes Cancer Care
Buffalo, New York, United States
RECRUITINGUniversity at Buffalo / Great Lakes Cancer Care
Buffalo, New York, United States
RECRUITINGThe feasibility of intermittent caloric restriction plus a plant-based diet in cancer patients receiving chemotherapy
enrollment rate
Time frame: 12 Months
The feasibility of intermittent caloric restriction plus a plant-based diet in cancer patients receiving chemotherapy
drop-out rate
Time frame: 12 Months
The feasibility of intermittent caloric restriction plus a plant-based diet in cancer patients receiving chemotherapy
compliance with diet measured by self-reports
Time frame: 12 Months
To obtain preliminary evidence of clinical efficacy of the combination of chemotherapy and intermittent caloric restriction
objective response rate (partial + complete response)
Time frame: 12 Months
To obtain preliminary evidence of clinical efficacy of the combination of chemotherapy and intermittent caloric restriction
progression-free survival (PFS)
Time frame: 12 Months
To obtain preliminary evidence of clinical efficacy of the combination of chemotherapy and intermittent caloric restriction
overall survival (OS)
Time frame: 12 Months
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