Improvement of the Operative Outcome in Patients With Primary VEGF + Unifocal Breast Cancer or DCIS Through the Intraoperative Visualization of the Tumor Using Molecular Imaging and Bevacizumab-IRDye-800CW

Inclusion Criteria: * women of age ≥ 18 years able to give consent who have been informed in detail about the study beforehand and have given written consent to participate * Patients with histologically confirmed unifocal VEGF-positive invasive breast cancer with an indication for BET * Patients with histologically confirmed unilateral VEGF-positive DCIS with an indication for BET * ECOG performance ≤ 2 * Pre-menopausal women had a negative pregnancy test prior to administration of the study medication * Negative pregnancy test (serum) within 10 days prior to administration of the test medication in all women of childbearing age with results available prior to the start of therapy (or postmenopausal; age ≥60 and no menses over ≥ 1 year without any other medical cause; or hysterectomy, or tube ligation, or bilaterally guided occlusion). Women of childbearing potential who are sexually active must agree that they and their partner may use effective contraception during the trial and for 3 months after participation Exclusion Criteria: * Second malignancy in the breast and other organs * Pregnant or breastfeeding patients * Planned sentinel lymph node marking using patent blue * Previous radiation therapy in the area to be examined * Known or suspected hypersensitivity to the study medication (according to IMPD / SmPC) or other immunoglobulins * Currently after neoadjuvant (primarily systemic) chemotherapy and anti-hormone therapy * Immunotherapy (e.g. monoclonal antibodies, cytokines or signal transduction inhibitors) in the last 28 days prior to the declaration of consent * Previous therapy with bevacizumab * Planned reconstruction in the breast to be examined * Previous surgery within the last 28 days prior to the declaration of consent * Non-healing wounds, ulcers or broken bones within the last 28 days prior to giving informed consent * Patients with ileus within the last 28 days prior to the declaration of consent * Non-adjustable hypertension (\> 145/90 mmHg) despite optimal drug therapy * Insufficient kidney function (serum creatinine\> 1.5 x upper limit of the normal range) * Current or recent treatment with another investigational drug in another clinical trial within 28 days of informed consent * Potentially fertile women without adequate contraception. Safe contraceptive measures are procedures with a Pearl index of ≤ 1% * Patients with other serious illnesses that pose an unreasonable risk for participating in the study * Persons who are in a dependent / employment relationship with the sponsor or investigator * Persons who are to be or are to be accommodated in an institution due to a court or official order