This project is a pilot randomized controlled trial aimed at investigating the potential of Carica Papaya Leaf Extract, available in a marketed pill formulation, in increasing platelet counts in live donor liver transplant recipients. Carica Papaya leaf extract has shown positive results in increasing platelet counts in various medical conditions such as Dengue, Immune thrombocytopenic purpura and chemotherapy induced thrombocytopenia. Thrombocytopenia i.e. low platelet counts are a common occurrence in patients with chronic liver disease undergoing live donor liver transplant. It has been observed in previous studies that live donor liver transplant recipients who have persistent thrombocytopenia have significantly worse outcomes as compared to patients who have higher platelet counts. Positive results in this study lead to further studies in assessing the impact of platelet augmentation in live donor liver transplant recipients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
Carica Papaya Leaf Extract 1100 mg X TDS started at least 3 days preoperatively and continued on post operative day 3 to day 7
Placebo will be given in a similar manner
Institute of Liver & Biliary Sciences
New Delhi, National Capital Territory of Delhi, India
RECRUITINGPOD 7 Platelet Counts
Time frame: 7th post-operative day
Pre-operative platelet counts
Time frame: 1 day prior to surgery
Intra-operative blood loss and transfusion requirements
Time frame: Day 0
Incidence of Early allograft dysfunction
Time frame: First 7 days following live donor liver transplant
Incidence of prolonged post-operative drainage
Time frame: First 14 days following live donor liver transplant
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.