To observe the effect of micro-conjunctival autografting combined with amniotic membrane transplantation on the postoperative recurrence, complications and ocular surface symptoms among patients with recurrent pterygium.
Recurrent pterygium is a common postoperative complication of pterygium surgery, the postoperative recurrence rate is about 1.44% and needs careful treatment. At present, surgical is the main and most effective treatment of recurrent pterygium. Among various surgical methods, autologous conjunctival transplantation is regarded as the first choice in normal conditions. However, the scope of conjunctival transplantation is positively correlated with the degree of ocular surface damage. Therefore, our research aimed to use micro conjunctival transplantation(1.5mm×3.0mm) to reconstruct limbal conjunctiva and amniotic membrane to cover the whole pterygium resection area to better protect conjunctival sac and ocular surface.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
1. Disinfection, anaesthesia and excision of recurrent pterygium are the same as conventional autologous conjunctival transplantation. 2. The biological freeze-dried amniotic membrane (Jiangxi Ruiji Biological engineering technology Co., Ltd., Nanchang, China), equivalent in size to the exposed scleral surface, was flat mounted on the exposed scleral area , and the amniotic membrane was fixed on the superficial sclera with 10-0 suture. 3. After amniotic membrane graft was fixed, 2% lidocaine was applied to the superior temporal conjunctiva. 4. Take the conjunctival epithelial graft with the length equivalent to the neck of recurrent pterygium and the width of 1.5mm \~ 2.0mm, and translate it on amniotic membrane surface near corneal limbus. The conjunctival flap was secured with 10-0 suture. 5. Last, tobramycin and dexamethasone eye ointment was applied and bandaged with dressing.
1. Routine disinfection and anaesthesia. 2. To bluntly separate and excise pterygium. 3. Remove pterygium tissue on the corneal surface with a round blade. 4. Place a cotton ball slightly infiltrated with diluent Bleomycin A5 Hydrochloride for Injection on the exposed sclera for 1 minute and flushed away later. 5. After anesthesia, take the superior temporal conjunctival epithelium equal to the size of the exposed scleral and translate it to the exposed scleral surface (the limbus side of the graft corresponds to the limbus of the graft bed), and fixed with 10-0 suture. 6. The free conjunctival margin of the conjunctival flap sampling area was sutured intermittently with 10-0 suture. 7. Apply tobramycin dexamethasone eye ointment and wrap the eyes with dressing after operation.
the Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
Changes of grade of conjunctival hyperplasia
Grade 1, no significant difference from normal eyes (no recurrence); Grade 2, a little episcleral vessels in the pterygium excision area, which extends to the corneoscleral limbus but does not exceed, and there is no fibrous tissue hyperplasia (no recurrence); Grade 3, having proliferative fibrous tissue in the resection area, which does not exceed the limbus (no recurrence); Grade 4, the cornea is invaded by proliferative fibrous tissue, and this grade is true pterygium recurrence (recurrence).
Time frame: Day 0#3#7 and14, Month 1#3 and 6.
Changes of Schirmer test I
5-minute Schirmer test I
Time frame: Day 0#3#7 and14, Month 1#3 and 6.
Changes of ocular surface symptom scores
Include dryness, burning, foreign body and pain sensation. The full score of each symptom is 100 points, with a score of 0 reflecting no discomfort, 100 was considered as the maximum discomfort.
Time frame: Day 0#3#7 and14, Month 1#3 and 6.
Changes of corneal epithelial repair time
Corneal fluorescein sodium staining was applied to assess the epithelial repair after operation.
Time frame: Day 0#3#7 and14, Month 1#3 and 6.
Changes of visual acuity
To observe the changes of visual acuity around operation.
Time frame: Day 0#3#7 and14, Month 1#3 and 6.
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