Obesity is a frequent disease mainly caused by environmental/polygenic factors and more rarely caused by the alteration of a single gene ("monogenic obesity"). The diagnosis of these rare forms can lead to personalized management (new treatments, prognosis, adapted hygienic and dietary rules) and family screening. The use of a panel covering the known causes of monogenic obesity on a pediatric cohort of severe and early obesity will allow to evaluate the relevance of these analyses to adapt the management of this type of patients.
Study Type
OBSERVATIONAL
Enrollment
100
The DNA study will be carried out from saliva sample 1 saliva sample per patient will be performed at the inclusion visit
Centre Hospitalier Universitaire de Bordeaux
Bordeaux, France
Positivity rate of patients for whom a diagnosis of monogenic obesity will be obtained when all analyses have been performed.
Time frame: Inclusion visit
Number of Patients eligible for a drug targeting single-gene obesity
Time frame: Inclusion visit
Number of patients for whom a genetic finding will have changed management and description of changes.
Time frame: Inclusion visit
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