Study to Assess the Safety, Tolerability and Pharmacokinetics of STI-1558 in Healthy Volunteers

Inclusion Criteria: * Body mass index (BMI) is between 18 and 30 kg/m2 (both inclusive), and Body weight between 45 and 100 kg (inclusive) * Generally normal, or abnormal with no clinical significance as judged by the primary investigator based on physical examination, vital signs, electrocardiogram, and clinical laboratory tests * Willing to follow contraception guidelines * Willing and able to comply with study procedures and follow-up visits Exclusion Criteria: * Difficulty or history of dizziness during venous blood collection or encountering blood or needles * Known or suspected pregnancy, planned pregnancy, a positive pregnancy test at screening or are breastfeeding * A clinically relevant intolerance or allergy to drugs, or are known or suspected to have hypersensitivity to any ingredient in STI-1558 capsules * Received an experimental agent within 1 month or 5 times half-life (whichever is longer) prior to the first dose of study drug * Has a history of gastrointestinal, liver or kidney disease, or other condition that may exclude the subject as determined by the investigator * Has a medical history of significant diseases as determined by the investigator * Has a history of febrile illness within 14 days prior to the first dose of study drug * Has values above the upper limit of normal alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase at screening or Day -1 and judged to be clinically significant by the investigator * Prolonged QTcF interval * Has had major surgery within 3 months prior to the first dose of study drug or plans to undergo surgery during the study * Any marketed medication within 14 days or 5 times the half-life, whichever is longer, prior to the first dose of study drug * Vaccinated within 14 days prior to the first dose of study drug or plans to be vaccinated during the study * Is unwilling to abstain from quinine containing products or grapefruit during the study * Use of BCRP substrates within 7 days prior to the first dose of study drug * A known history of drug abuse within 2 years before screening or positive drug abuse test at screening * Blood donation or blood loss \> 400 mL within 3 months prior to screening * Weekly alcohol consumption of more than 14 units of alcohol in any week within the past 3 months prior to screening, or intake of alcohol within 48 hours prior to first dose of study drug, or cannot abstain from alcohol during the study, or positive breath alcohol test at screening or Day -1 * Significant smoking history within 3 months before screening * Excessive drinking of caffeinated beverages within 3 months before screening, or intake of caffeine-containing products within 48 hours prior to the first dose of study drug * Have human immunodeficiency virus (HIV) infection, human T-cell leukemia virus type 1 (HTLV1) infection, or hepatitis B virus (HBV) or hepatitis C virus (HCV) viremia or are at risk for HBV reactivation (at risk for HBV reactivation is defined as being HBs antigen positive, or anti-HBc-antibody positive), or are positive for HBV deoxyribonucleic acid (DNA). HCV ribonucleic acid (RNA) must be undetectable by laboratory test * Positive SARS-CoV-2 test on Day -1 * Subjects who are judged as not eligible to participate in this study as determined by the investigator or designee