The Effect of Meal Replacement on the Time to Reach the Blood Glucose Target in Patients With Type 2 Diabetes Mellitus

Inclusion Criteria: 1. Type 2 diabetic patients who meet the diagnosis of type 2 diabetes (CDS2020) and are willing to receive intensive insulin hypoglycemic therapy; 2. Glycated hemoglobin A1c≥7.5%; 3. Age between 18-70 years old, body mass index (BMI) 20-35kg/m2; 4. Be able and willing to cooperate with diet and exercise and monitor blood sugar in accordance with the project regulations, and agree to sign the informed consent. Exclusion Criteria: 1. Diagnosed as type 1 diabetes or special type of diabetes; 2. Allergic or intolerable to the meal replacement food used in the study; 3. Acute complications of diabetes (including DKA, HHS, lactic acidosis) 4. Severe microvascular complications: proliferative retinopathy; urine AER\>300mg/g or urine protein positive, quantitative\>0.5g/d; uncontrolled painful diabetic neuropathy and significant diabetic autonomic neuropathy; 5. Significant macrovascular complications: patients with acute cerebrovascular accident, acute coronary syndrome, peripheral arterial disease requiring vascular intervention or amputation within 12 months before enrollment; 6. Serum creatinine clearance rate is less than 50ml/min/1.73m2 (calculated according to CKDEPI formula), alanine aminotransferase ≥ 3 times the upper limit of normal, and total bilirubin ≥ 2 times the upper limit of normal; 7. The cumulative time of using drugs that may affect blood sugar for more than 1 week within 12 weeks, such as oral/intravenous glucocorticoids, GH, estrogen/progestin, high-dose diuretics, antipsychotics, etc.; 8. Systemic infection or serious concomitant diseases; patients with malignant tumors or chronic diarrhea; 9. Uncontrolled endocrine gland dysfunction; 10. Mental or communication disorders; 11. Pregnant and lactating women; 12. The subject is not cooperative, or the investigator judges that it may be difficult to complete the investigator; 13. Other circumstances judged by the investigator to be unsuitable for inclusion.