This randomized controlled trial will focus on the effects of early oral nutritional supplementation on immune function in elderly patients with mild to moderate COVID-19 on maintenance hemodialysis. The purpose of this study is to determine whether early oral nutritional supplementation can improve immune function and clinical outcomes.
COVID-19 is in the midst of a global pandemic. Elderly patients are often susceptible and at high risk. Elderly patients on maintenance hemodialysis are often accompanied by a variety of complications, malnutrition is a common complication with an incidence of 23-73%. Due to a variety of risk factors, COVID-19 infection tends to develop into severe disease, and it takes longer for nucleic acid to turn negative. This randomized controlled trial will focus on the effects of early oral nutritional supplementation on immune function in elderly patients with mild to moderate COVID-19 on maintenance hemodialysis. The purpose of this study is to determine whether early oral nutritional supplementation can improve immune function and clinical outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
112
Enteral nutritional emulsion(TPF-T) will be given by oral intake,400ml per day, lasting for 7-10 days.
Nutritional treatment advice will be given
CD4 lymphocyte counts
Time frame: Baseline to discharge date, an average of 3 weeks
lymphocyte count
Time frame: Baseline to discharge date, an average of 3 weeks
T-lymphocyte subsets
CD3+, CD4+, CD8+
Time frame: Baseline to discharge date, an average of 3 weeks
Change in body weight
Time frame: Baseline to discharge date, an average of 3 weeks
change in white blood cell count
Time frame: Baseline to discharge date, an average of 3 weeks
change in hemoglobin
Time frame: Baseline to discharge date, an average of 3 weeks
change in albumin
Time frame: Baseline to discharge date, an average of 3 weeks
change in C-Reactive Protein
Time frame: Baseline to discharge date, an average of 3 weeks
change in procalcitonin
Time frame: Baseline to discharge date, an average of 3 weeks
change in nutritional risk screening 2002(NRS 2002) score
Scores range from 0 to 7，a score greater than or equal to 3 indicates nutritional risk
Time frame: Baseline to discharge date, an average of 3 weeks
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change in mini nutritional assessment short-form（MNA- SF） score
Scores range from 0 to 14，a score of 0 to 7 indicates malnutrition，8-11 indicates risk of malnutrition, 12-14 indicates normal nutrition
Time frame: Baseline to discharge date, an average of 3 weeks
change in Geriatric nutritional risk index(GNRI) score
Higher scores mean a worse outcome
Time frame: Baseline to discharge date, an average of 3 weeks
Length of hospital stay
Time frame: Baseline to discharge date, an average of 3 weeks