a single blinded randomized controlled clinical trial that was conducted to evaluate the role of zinc supplementation in improving the outcome of infants and children with sepsis in pediatric intensive care unit.
a single blinded randomized controlled clinical trial that was conducted to evaluate the role of zinc supplementation in improving the outcome of infants and children with sepsis in pediatric intensive care unit. The study included 72 cases that were randomly divided into 2 groups A- Group A (Zinc treated group): Included 36 cases who received oral zinc sulfate supplementation at doses ranging from 10 mg (infants) to 20 mg (under-five children) of elemental zinc per day, a dosage that is safe in these children. B- Group B: Included 36 cases who didn't receive zinc sulfate supplementation. Method of randomization: The cases were randomly divided into two groups using the closed envelope technique. The numbers from 1 to 72 were written in flat pieces of papers and put in closed envelopes that were randomly distributed to the participants. The cases with the odds number were allocated to the zinc treated group while the cases with the even numbers were allocated to the other group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
72
Oral zinc sulfate at dose 10 to 20 mg daily for 10 days
Mansoura University Children's Hospital
Al Mansurah, Egypt
Mortality rate
Frequency of occurrence of death
Time frame: through study completion an average of one year
Zinc level
serum zinc level
Time frame: after 10 days of treatment
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