Lesion Contiguity in Very High Power-short Duration Ablation

University of Barcelona128 enrolled

Overview

This observational trial investigates the effect of very high power-short duration radiofrequency ablation on lesion contiguity as assessed by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR). Patients with paroxysmal or early persistent atrial fibrillation (AF) scheduled for pulmonary vein isolation (PVI) undergo point-by-point ablation using the QDOT micro catheter applying Qmode+ (90W over 4 seconds). All patients receive an LGE-CMR 3 months after the procedure for ablation lesion assessment. Contiguity of LGE-CMR-detected ablation lesions will be compared with a matched control group of patients that have undergone PVI accomplished by ablation index-guided ablation with 40 W following the CLOSE protocol.

Study Type

OBSERVATIONAL

Enrollment

128

Conditions

Atrial Fibrillation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * paroxysmal or early persistent (max. 3 months) atrial fibrillation * scheduled for PVI-only catheter ablation Exclusion Criteria: * long-standing persistent atrial fibrillation * previous left atrial ablation * claustrophobia preventing CMR * sever renal insufficiency (GFR \>30 ml/min) * gadolinium contrast allergy * presence of implantable devices not compatible with magnetic resonance * pregnancy and lactation

Locations (1)

Hospital Clinic, University of Barcelona

Lesion Contiguity in Very High Power-short Duration Ablation

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts