A Clinical Trial to Evaluate the Safety and Effectiveness of MatrixOssTM Bone Graft

Inclusion Criteria: 1. Male or female patients aged 18-65 years (including 18 years and 65 years); 2. Bone loss caused by singe tooth extraction requiring bone grafting; 3. At least one natural tooth adjacent to the targeted tooth; 4. The subjects could understand the purpose of this trial, voluntarily participate in this trial and willing to sign an Informed Consent Form (ICF). Exclusion Criteria: 1. Bone defect caused by invasive or malignant bone tumors； 2. Subjects with uncontrolled periodontitis, acute periapical inflammation; 3. Subjects who are receiving or had received any drug in last 3 months that may influence or promote bone metabolism; 4. Active infectious disease, various bone defects during the active phase of metabolic bone disease; 5. Subjects with acute or chronic infection (osteomyelitis) at the surgical site; 6. Subjects with osteoporosis or osteomalacia; 7. Alanine Aminotransferase，ALT）Aspartate Aminotransferase，AST） Subjects with abnormal liver or kidney functions (ALT or AST or creatinine exceeds 1.5 times the upper limit of normal range); 8. Subjects who has a history of or is undergoing cervico-facial radiotherapy or chemotherapy; 9. Subjects with serious blood system diseases, such as leukemia or other hemorrhagic diseases; 10. Subjects with abnormal coagulation function; 11. Subjects with severe cardiovascular and cerebrovascular diseases; 12. Subjects with systemic diseases may affect postoperative healing and/or osseointegration, such as diabetes, uncontrolled hypertension (systolic blood pressure ≥160 mmHg and/or diastolic blood pressure ≥100 mmHg), hyperparathyroidism, etc. 13. Subjects with mental disorder and lack of behavioral autonomy; 14. Known allergy or hypersensitivity to animal-derived implantable materials; 15. Subjects who refuse to use porcine-derived implantable materials; 16. Pregnant and lactating women, or those who plan to conceive within 6 months; 17. Subjects with implants adjacent to the targeted teeth that can cause oral imaging artifacts, such as metal dentures, porcelain teeth, etc. that may cause oral imaging artifacts; 18. Subjects who smoking more than 5 cigarettes per day; 19. Subjects who are alcoholism, drug abuse, or drug dependence; 20. Subjects who have participated or are participating in a drug clinical trials in last 3 months, or have participated in other medical device clinical trials in last 30 days; 21. Other circumstances which are considered by the investigator not suitable for enrollment in this study.