Patients with hepatitis c showed increased level of oxidative stress. Increased level of serum lipid peroxidation leads to the production of toxic mediators as malondialdehyde (MDA) which lead to disease progression. Chronic stress shunt tryptophan which is essential amino acid toward kynurenic pathway leading to lower level of serotonin and melatonin level. Currently, direct-acting antivirals (DAAs) show well-established efficacy against hepatitis C virus (HCV).
Study Type
OBSERVATIONAL
Enrollment
50
hepatitis C patients will be treated by direct acting antiviral drugs (DAAs)for 12 weeks.
Change in malondialdehyde (MDA) level.
Malondialdehyde (MDA) levels will be measured by the TBARS assay (thiobarbituric acid reactive substance assay)
Time frame: 12 weeks following end of treatment.
Change in melatonin level.
Melatonin will be measured by using immunological method.
Time frame: 12 weeks following end of treatment.
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