Physiological Effects of HFNC During Exercise in Patients With Fibrosing Interstitial Lung Diseases

ADIR Association16 enrolled

Overview

in this study, the investigators aim to describe the effects of highflow nasal canulae oxygen therapy (HFNC) on respiratory muscle function during exercise in patients with fibrosing interstitial lung diseases (ILD) during an endurance test

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Interstitial Lung Disease Pulmonary Rehabilitation

Interventions

high flow nasal canulaeDEVICE

high flow nasal canulae is a oxygen therapy technic which allows the administration of warmed and humidified oxygen with a flow up to 50L/Min and a monitored FiO2. Physiological previous studies reported various effects of this technic especially on work of breathing. In our study the investigators aim to test this physiological property during exercise.

Ventury maskDEVICE

Ventury mask is a oxygen therapy technic which allows the administration with a mask of oxygen with a flow up to 15L/Min and a monitored FiO2.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cared for as part of a respiratory rehabilitation program (ADIR association) * Presenting diffuse fibrosing interstitial pneumonitis, documented by CT scan data and whatever its etiology * Presenting severe hypoxemia in ambient air (SpO2\<90%) during an exercise test (6-minute walk test or functional exercise test) Exclusion Criteria: * Patient with a contraindication to carrying out a respiratory rehabilitation program * Patient having presented an exacerbation of PID, pneumothorax or pneumomediastinum in the 3 months preceding potential inclusion * Tracheostomized patient * Patient with a contraindication to the placement of a nasogastric tube * Pregnant or breastfeeding women or women of childbearing age without effective means of contraception (a pregnancy test will be carried out) * Protected adult patient (guardianship or curatorship) * Patient deprived of liberty by court or administrative decision * Refusal of patient participation or consent

Locations (1)

ADIR association

Bois-Guillaume, France

RECRUITING

Outcomes

Primary Outcomes

Ptdi swing

To compare the change in transdiaphragmatic pressure between baseline and peak during inspiration (Ptdi swing) between HFNC and VM in patients with fibrosing Interstitial Lung Disease in stable state, at isotime.