Phase I Clinical Trial of COVID-19 mRNA Vaccine in Adults Aged 18 Years and Older

Inclusion Criteria: 1. Adults aged 18 years and above with BMI of 18 to 30 (including boundary values); 2. Volunteers are able and willing to comply with the requirements of the clinical trial protocol, and volunteers or witnesses can sign informed consent forms; 3. Willing to discuss the medical history with the investigator or doctor and allow access to all medical records related to this trial; 4. Provide 48-hour PCR negative report; 5. Have not received any other COVID-19 vaccines. Exclusion Criteria: * Criteria for exclusion of the first dose 1. Other medical or psychiatric conditions, including recent (within the past year) or current presence of suicidal ideation/behavior, or laboratory abnormalities that may increase the risk of participating in the study, or subjects who are not suitable to participate in the study according to the investigator's judgment; 2. Positive for human immunodeficiency virus (HIV); 3. History of infection or disease of Middle East Respiratory Syndrome (MERS), SARS or other coronaviruses or related immunizations; 4. History of serious adverse reactions associated with the vaccine and/or a history of severe allergic reactions (e.g., anaphylaxis) to any component of the vaccine under study; 5. Immunocompromised patients with known or suspected immunodeficiency identified by medical history and/or physical examination; 6. Bleeding constitution or condition associated with prolonged bleeding which investigators believe that intramuscular injection is contraindicated; 7. Women who test positive for blood pregnancy or are breastfeeding, volunteers or their partners have a pregnancy plan within 12 months; 8. Severe hypertension and uncontrollable medication (on-site measurement: systolic blood pressure ≥ 160mmHg, diastolic blood pressure ≥ 100mmHg); 9. Have a serious chronic disease or the condition is in the progression period can not be smoothly controlled, such as diabetes, thyroid disease, etc.; 10. History of severe myocarditis, pericarditis and other heart diseases; 11. Abnormal laboratory tests during the screening window and judged by researchers to be of clinical significance; 12. Plans to receive other vaccines within 28 days before and after receiving the test vaccine; 13. Those receiving immunosuppressive therapy, including cytotoxic drugs or systemic corticosteroids, such as for cancer or autoimmune diseases, or who were scheduled to receive treatment throughout the study period. If systemic corticosteroids are used in a short period of time (\< 14 days) for the treatment of acute illness, subjects should not enter this study until at least 28 days after corticosteroid therapy has been discontinued prior to study vaccination. Inhalation/spraying, intra-articular, intraskeletal, or topical (skin or eyes) use of corticosteroids is permitted; 14. Receiving blood/plasma products or immunoglobulins 60 days prior to study vaccination or plan to receive for the entire study duration; 15. Engage in other interventional studies within 28 days prior to entering the study and/or during the study's participation; 16. Participated in other interventional studies of lipid-containing nanoparticles; 17. Have symptoms of COVID-19 such as respiratory symptoms, fever, cough, shortness of breath, and dyspnea; 18. Fever, axillary temperature \> 37.0 °C. Second dose exclusion criteria: 1. Severe allergic reactions occur after the first vaccination; 2. Serious adverse reactions with causal relationship during the first vaccination; 3. Those who are newly discovered or newly occurring after the first vaccination do not meet the inclusion criteria of the first dose or meet the exclusion criteria of the first dose, and the investigator shall decide whether to continue to participate in the study; 4. Other reasons for exclusion that the investigators believe.