A pilot randomized feasibility trial with a blinded evaluator.
Chemotherapy-induced peripheral neuropathy (CIPN) has a dose limiting effect which can greatly affect quality of life and often limits the amount of treatment patients can receive in treating their cancer. In the discipline of hand therapy, there is a science-based body of knowledge with effective protocols to treat neuropathies associated with injury and disease. These interventions have not been explored on patients with CIPN.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
49
Patient will participate until the time of onset of CIPN of the hands or through 84 days of treatment if no symptoms of CIPN.
HonorHealth Research Institute
Scottsdale, Arizona, United States
Change in Cutaneous Sensation
measured by CTCAE Version 4
Time frame: time of consent until the time of onset of CIPN of the hands or through 84 days of treatment
Change in pain
measured by visual analog scale
Time frame: time of consent until the time of onset of CIPN of the hands or through 84 days of treatment
Change in moving touch sensation
measured by TEN test
Time frame: time of consent until the time of onset of CIPN of the hands or through 84 days of treatment
Change in innervation density
measured by Two Point Discrimination Test
Time frame: time of consent until the time of onset of CIPN of the hands or through 84 days of treatment
Change in pressure threshold sensation
measured by monofilament test
Time frame: time of consent until the time of onset of CIPN of the hands or through 84 days of treatment
Change in peripheral nerve tolerance at the thoracic level of the right and left arm
measured by elevated arm stress test
Time frame: time of consent until the time of onset of CIPN of the hands or through 84 days of treatment
Change in median nerve tolerance at the right and left volar wrist
measured by Phalen's test
Time frame: time of consent until the time of onset of CIPN of the hands or through 84 days of treatment
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Change in ulnar nerve tolerance at the right and left elbow
measured by elbow flexion test
Time frame: time of consent until the time of onset of CIPN of the hands or through 84 days of treatment
Indication of irritability of the median and ulnar nerve at the right and left wrist
measured by Tinel test
Time frame: time of consent until the time of onset of CIPN of the hands or through 84 days of treatment