A Study to Learn About Abrocitinib Tablets in People With Atopic Dermatitis in India

Inclusion Criteria: This study is seeking participants who: 1. Must be of 12 years of age or older, at the time of informed consent. 2. Meet all the following Atopic Dermatitis (AD) criteria: * Clinical diagnosis of chronic AD (also known as atopic eczema) for at least 1 year prior to Day 1 and has confirmed AD (Hanifin and Rajka criteria of AD10). * Moderate to severe AD (affected body surface area (BSA) ≥10%, Investigator's Global Assessment (IGA) ≥3, Eczema Area and Severity Index (EASI) ≥16, and Peak Pruritus Numerical Rating Scale (PP-NRS) ≥4 at the baseline visit); * Documented recent history (within 6 months before the screening visit) of inadequate response to treatment with topical medications for at least 4 weeks, or for whom topical treatments are otherwise medically inadvisable (eg, because of important side effects or safety risks), or who have required systemic therapies for control of their disease. 3. Negative pregnancy test for females of childbearing potential at Screening. Female participants of childbearing potential must agree to use a highly effective method of contraception for the duration of the active treatment period and for at least 28 days after the last dose of study intervention. 4. Body weight ≥25 kg at Baseline 5. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the Informed Consent Document (ICD) and in this protocol. Evidence of a personally signed and dated ICD indicating that the participant (or a legally acceptable representative, parent(s)/legal guardian) has been informed of all pertinent aspects of the study. For minors under the age of legal consent in India, assent of the participating child needs to be documented for the age range 12 to 18 years in addition to the parental informed consent. Exclusion Criteria: This study does not include participants who: 1. Currently have active forms of other inflammatory skin diseases or have evidence of skin conditions (eg, psoriasis, seborrheic dermatitis, lupus). 2. A current or past medical history of conditions associated with thrombocytopenia, coagulopathy or platelet dysfunction or QT interval abnormalities. 3. Have increased risk of developing venous thromboembolism, eg, deep vein thrombosis or pulmonary embolism: 4. Have a history of any lymphoproliferative disorder such as Epstein Barr virus (EBV) related lymphoproliferative disorder, history of lymphoma, leukemia, or signs or symptoms suggestive of current lymphatic or lymphoid disease. 5. Past history or active infection with Mycobacterium tuberculosis (TB), disseminated herpes zoster or disseminated herpes simplex, human immunodeficiency virus (HIV), Hepatitis B, or Hepatitis C. 6. Have any malignancies or have a history of malignancies with the exception of adequately treated or excised non-metastatic basal cell or squamous cell cancer of the skin, or cervical carcinoma in situ. 7. Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgement, make the participant inappropriate for the study. Any psychiatric condition including recent or active suicidal ideation or behavior that met any of the following criteria when screened for during the main study: * Suicidal ideation associated with actual intent and a method or plan in the past year: "Yes" answers on items 4 or 5 of the Columbia suicide severity rating scale (C-SSRS); * Previous history of suicidal behaviors in the past 5 years: "Yes" answer (for events that occurred in the past 5 years) to any of the suicidal behavior items of the C-SSRS; * Any lifetime history of serious or recurrent suicidal behavior; * The presence of any current major psychiatric disorder that is not explicitly permitted in the inclusion/exclusion criteria; * In the opinion of the investigator or Pfizer (or designee) exclusion is required. 8. Prior treatment with systemic janus kinase (JAK) inhibitors. 9. Participants who are vaccinated with live attenuated vaccine within the 6 weeks prior to the first dose of abrocitinib or who are expected to be vaccinated with these vaccines during treatment or during the 6 weeks following discontinuation of abrocitinib. 10. Have received any of the following treatment regimens specified in the timeframes outlined below: Within 1 year of first dose of study intervention: * Prior treatment with non B cell-specific lymphocyte depleting agents/therapies (eg, alkylating agents \[eg, cyclophosphamide or chlorambucil\], total lymphoid irradiation, etc.). Participants who have received rituximab or other selective B lymphocyte depleting agents (including experimental agents) are eligible if they have not received such therapy for at least 1 year prior to study baseline and have normal cluster of differentiation (CD) 19/20+ counts by fluorescence activated cell sorting (FACS) analysis. Within 12 weeks of first dose of study intervention: * Biologic drugs that have immunomodulatory properties or could be used to treat AD: within 12 weeks of first dose of investigational product or 5 half-lives (if known), whichever is longer. Other biologics without immunomodulatory properties (eg, insulin) are permissible at the judgement of the Investigator. Within 4 weeks of first dose of study intervention: * Use of oral immunosuppressive drugs (eg, Cyclosporine A (CsA), azathioprine, methotrexate, systemic corticosteroids, mycophenolate mofetil, Interferon gamma) within 4 weeks of first dose of study intervention or within 5 half-lives (if known), whichever is longer. NOTE: Systemic corticosteroids must be discontinued before Study Day 1, but a specific timeframe for discontinuation prior to first dose of abrocitinib is not required. NOTE: Corticosteroid inhalers and intranasal sprays are permissible. NOTE: Ophthalmic corticosteroids are permissible. Within 1 week of first dose of study intervention: * Anti-platelet drugs. Note: low dose acetyl salicylic acid (\<100 mg once daily \[QD\]) is permitted, for the purpose of cardiovascular prophylaxis, at the discretion of the investigator. 11. Require treatment with prohibited concomitant medication(s) or have received a prohibited concomitant medication. 12. Participation in other studies involving investigational drug(s) or vaccine within 8 weeks or within 5 half-lives (if known) whichever is longer, prior to study entry and/or during study participation. 13. Any of the following abnormalities in clinical laboratory tests at Screening: * Absolute neutrophil count of \<1.0 × 109/L (\<1000/mm3); * Platelet count of \<150 × 109/L (\<150,000/mm3); * Absolute lymphocyte count of \<0.50 × 109/L (\<500/mm3); * Estimated Creatinine Clearance \<60 mL/min using the Cockcroft Gault method; * Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) values \>2 times the Upper Limit of Normal (ULN); * Total Bilirubin (TBili) ≥1.5 times the ULN. 14. Pregnant or breastfeeding women, or women of childbearing potential who are unwilling to use highly effective contraception consistently and correctly for the entire duration of the study and for at least 28 days after the last dose of study intervention. 15. Investigator site staff or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members.