Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA)

BILLOIR200 enrolled

Overview

Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain. The consequence is synthesis of altered haemoglobin S (HbS) which polymerises in red blood cell (RBC) at deoxygenated state. SCD is associated with chronic haemolytic anaemia, vaso-occlusive crisis (VOC) leading to frequent hospitalisation. The aim of the study was to to investigate whether a combination of routine laboratory biomarkers of haemolysis could be used to predict VOC development in confirmed SCD patients.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Sickle Cell Disease Vaso-occlusive Crisis

Interventions

Erythrocytic parameters and thrombin generation assay measurementBIOLOGICAL

Erythrocytic parameters and thrombin generation assay measurement

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Sickle cell disease Exclusion Criteria: * \<18 years * pregnancy * Patient under protective guardianship or curatorship

Locations (1)

Rouen university Hospital

Rouen, France

RECRUITING

Outcomes

Primary Outcomes

Hospitalisation for Vaso-occlusive crisis within one years

Following injury consultation, evaluation of biological markers predicting vaso-occlusive crisis requiring hospitalisation in the year

Time frame: 1 year

Data from ClinicalTrials.gov

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