The investigators evaluate the activation and connectivity of patients' motor regions in the acute phase of ischemic stroke by fNIRS.
This study aims to analyze the progress of brain recovery from upper-limb deficit due to acute ischemic stroke, using Functional Near-infrared Spectroscopy(fNIRS) as the main neural imaging method. Fifty patients having experienced a stroke onset within seven days will be recruited from the emergency room. The fNIRS signals will be recorded bilaterally over the contralateral sensorimotor cortex, the premotor area, the supplementary motor area, the primary motor cortex for 14 days after being diagnosed. Then compute activation and connectivity of the regions. The motor function data measured by the assessment scales, as well as the behavioral record during the fNIRS motor tasks will be collected as well.
Study Type
OBSERVATIONAL
Enrollment
50
Xuanwu Hospital, Capital Medical University
Beijing, China
RECRUITINGfNIRS characteristics of upper limb movement
The changes in brain oxygen levels are collected in two wavelengths, including 845 and 763 nanometers using a 44 channeled fNIRS machine. The data is used to determine the position of the activated area of the brain and functional connectivity during the movement. The locations of fNIRS channels on the skull of individuals are determined due to the observations on the cortical regions of interest (ROIs), namely the contralateral sensorimotor cortex (SMC), the contralateral premotor cortex (PMC) and primary motor cortex (M1), etc.
Time frame: 0-14 day
Assessment of upper limb function
Recording the quality and frequency of fNIRS motion tasks including grip and reach-out movements.
Time frame: 0-14 day
Assessment of upper limb function
Evaluating the motor function by Action Research Arm Test.
Time frame: 0-14 day
Assessment of upper limb function
Evaluating the motor function by Fugl-meyer assessment.
Time frame: 0-14 day
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