The main purpose of this study is to investigate the safety and tolerability of the study drug LY3457263 when administered alone or in combination with glucagon-like peptide 1 (GLP-1) receptor agonist (RA) in participants with type 2 diabetes. Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study will last up to approximately 16 weeks excluding the screening period for each participant and include up to 17 visits.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
94
Pinnacle Research Group, LLC
Anniston, Alabama, United States
CenExel ACT
Anaheim, California, United States
Qps-Mra, Llc
South Miami, Florida, United States
Atlanta Center of Medical Research
Atlanta, Georgia, United States
Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
A summary of TEAEs, SAEs and other non-serious adverse events (AEs), regardless of causality, will be reported in the Reported Adverse Events module
Time frame: Predose up to 16 weeks
PK: Area Under the Concentration Versus Time Curve (AUC) of LY3457263
PK: AUC of LY3457263
Time frame: Pre-dose on Day 1 up to 85 days post-dose
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CenExel-HRI
Berlin, New Jersey, United States