Thyroid Nodule Gene Sequencing in a Danish Population

N/AActive Not RecruitingNCT05377736

Aarhus University Hospital30 enrolled

Overview

This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population. Patients with thyroid nodules suspected of malignancy is included prospectively. Tissue samples are collected for molecular analyses form surgical specimens and bloodsamples, and preoperative clincial features are registered.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Thyroid Nodule (Diagnosis)Thyroid Cancer

Interventions

Molecular analysesGENETIC

Collect thyroid tissue for molecular analysis from the histological specimen collected by routine surgery

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Thyroid nodule \>1.5 cm * BSRTC: IV, V, og VI Exclusion Criteria: * No surgical specimen available * Purely cystic nodules

Locations (1)

Aarhus Universityhospital

Aarhus N, Denmark

Outcomes

Primary Outcomes

DNA alterations

Whole genome sequencing by next generation sequencing

Time frame: Two years

RNA alterations

Total RNA sequencing including circular RNA, micro RNA and messenger RNA

Time frame: Two years

DNA methylation

Whole Genome Bisulfite Sequencing

Time frame: Two years

Circulating tumor DNA

Whole genome sequencing of leucocyt DNA and circularing DNA

Time frame: Two years

Data from ClinicalTrials.gov

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