Placental Pathology and Inflammatory Factor Analysis of OAPS

Peking University People's Hospital40 enrolled

Overview

This investigation is on placental pathological changes and inflammatory factors associated with obstetric antiphospholipid syndrome.

1\. To clarify the correlation between antiphospholipid antibody, ACC1 expression level, Treg cell and placental pathological changes associated with antiphospholipid syndrome. 2. Reveal that antiphospholipid antibodies affect Treg cell differentiation through the key enzyme of lipid metabolism ACC1.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Antiphospholipid Syndrome in Pregnancy

Interventions

no interventionOTHER

no intervention

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. pregnant women with antiphospholipid syndrome (diagnosed by experts with clinical evidence) and healthy pregnant women without antiphospholipid syndrome as a control group 2. consent to join this study and finish the informed consents Exclusion Criteria: pregnant women with other autoimmune diseases

Locations (1)

PekingUPH

Beijing, China

RECRUITING

Outcomes

Primary Outcomes

expression of ACC1 in placenta in pregnancy with/without antiphospholipid syndrome

Time frame: in two years

Central Contacts

Jingjing Yang, deputy chief physician, doctor

CONTACT

0086-13810625484 yjjbear2013@126.com

Xinyang Ma, resident, bachelor

CONTACT

0086-18801152801 2948138462@qq.com

Data from ClinicalTrials.gov

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