This experimental randomized, double-blind, and controlled study included fifteen young, healthy, and pain-free men and 15 age-matched women. It lasted for three visits with at least one-week washout. Pain was experimentally induced, twice at each visit, with intramuscular injections of 0.2 mL hypertonic saline (5%), before and after intake of one of the different chocolate-types; white (30% cocoa-content), milk (34% cocoa-content), dark (70% cocoa-content). Pain duration, pain area, peak pain, and pressure pain threshold were assessed every fifth minute after each injection, between the time-points 5 to 30 min. Prior to inclusion, all participants underwent an examination in a dental chair. This included a clinical examination of the orofacial region according to the Diagnostic Criteria for temporomandibular disorders (DC/TMD) by a blinded examiner. Participants were also examined regarding their psychosocial status prior to inclusion, this included depression, somatization, anxiety, pain catastrophizing and stress.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
30
pain was induced by intramuscular injections of hypertonic saline (5%)
pain was induced by intramuscular injections of hypertonic saline (5%)
Karolinska Institutet, Department of Dental Medicine
Huddinge, Sweden
Change in pain intensity by intake of chocolate
Pain intensity will be assssed using a 0-100 visual analoge scale (0-no pain; 100-worst pain ever experienced)
Time frame: 5 min after injection of hypertonic saline
Change in peak pain intensity before and after intake of chocolate
Peak pain intensity will be asessed from the 0-100 visual analoge scale (0-no pain; 100-worst pain ever experienced)
Time frame: 5 min after injection of hypertonic saline
Change in pain duration by intake of chocolate
Pain duration is assessed in seconds.
Time frame: Pain duration up to 300 seconds after injection of hypertonic saline
Change in pain area by intake of chocolate
Pain area will be marked on lateral charts of the head before and after intake of chocolate and measured in au.
Time frame: Pain area is marked 5 min after injection of hypertonic saline
Change in pressure pain threshold by intake of chocolate
Pressure pain thresholds are assessed using a digital algometer over the area of injection in the masseter muscle with a pressure rate of 30kPa/s.
Time frame: Pressure pain thresholds are assessed 5 min after injection of hypertonic saline
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