Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function

Early Phase 1CompletedNCT05379959

University of Chicago43 enrolled

Overview

To study the effects of MDMA, compared to a prototypical stimulant, on social motivation, social ability, and neural indices of social function in healthy volunteers

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Stimulant Use MDMA ('Ecstasy')Social Behavior Motivation

Interventions

MDMADRUG

Participants will be given 125 mg of MDMA.

MethamphetamineDRUG

Participants will be given 20 mg of MA.

placebo oral tabletDRUG

Participants will be given a placebo capsule that will only contain lactose.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI between 19 and 30 (no one under 130 lbs) * Smokers smoking less than 25 cigarettes per week * Have used ecstasy no more than 40 times with no adverse responses. Exclusion Criteria: * High blood pressure * Any medical condition requiring regular medication * Individuals with a current (within the last year) DSM-IV Axis 1 diagnosis * Individuals with a history of dependence on stimulant drugs. * Women who are pregnant or trying to become pregnant

Locations (1)

University of Chicago

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Profile of Mood States

The POMS measures individuals' mood states. This is a validated scale to measure positive and negative mood states. The POMS contains 30 items and assesses six identified mood factors: Tension-Anxiety, Depression-Ejection, Anger- Hostility, Vigor-Activity, Fatigue-Inertia, and Confusion-Bewilderment. Scoring of the instrument provides a global score of 0 to 120 or individual domain scores. Lower scores indicate better mood state. The POMS brief form is a simple self-rating instrument.

Time frame: Time Frame: Baseline-72 hours after completion of the sessions

Data from ClinicalTrials.gov

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