Faster Peritoneal Solute Transfer Rate and Survival in a Pre-APD and Icodextrin Peritoneal Dialysis Cohort

RenJi Hospital430 enrolled

Overview

A fast peritoneal solute transfer rate (PSTR) has been linked to worse survival especially in continuous ambulatory peritoneal dialysis (PD) cohort. In more recent cohorts, where automated PD and icodextrin were more widely used, this association disappears. The current study intended to clarify whether fast PSTR is related to worse outcome in this single center cohort with minimal use of APD and no icodextrin and otherwise modern management practice. Our study found that baseline PSTR predicted patient outcome in univariate survival analysis but not in multivariate analysis. The relationship between comorbidity and faster baseline PSTR may partly explain it.

Study Type

OBSERVATIONAL

Enrollment

430

Conditions

Peritoneal Dialysis

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients are Han Chinese; 2. Patients prepare for dialysis in our center, and start PD within 3 months after abdominal catheterization; 3. Patients successfully complete the first peritoneal equilibration test(PET); 4. Follow up regularly in our PD center. Exclusion Criteria: 1. Patients from hemodialysis to peritoneal dialysis; 2. Patients who need peritoneal dialysis due to transplant-renal loss;

Outcomes

Primary Outcomes

The relationship between fast PSTR and worse outcome in PD.

Baseline PSTR predicted patient outcome in univariate survival analysis but not in multivariate analysis. The relationship between comorbidity and faster baseline PSTR may partly explain it.