Safety and Efficacy Evaluation of Next-generation CD19-UCART

Inclusion Criteria: 1. Voluntary to participate in this clinical study and sign informed consent form; 2. The expected survival period is at least three months; 3. There is no other severe cardiopulmonary disease, and the liver and kidney function are normal (except for the subject with tumor lesions in the liver and kidney); 4. Patients cannot benefit from autologous CAR-T cell therapy due to T cell separation failure or CART amplification failure in the preparation of autologous CART, or the failure to complete apheresis or disease progression; Or the content of T cells in PBMC of peripheral blood is less than or equal to 10%; Or the disease is not effectively controlled within one month after autologous CAR-T transfusion, and the patient cannot receive CAR-T transfusion again; 5. The test results show that CD19 is positive in the tumor; 6. Patients with relapsed or refractory CD19-positive acute B-lymphocyte leukemia or B-cell non-Hodgkin's lymphoma. Patients with r/r B-ALL: 1 years old ≤ patient age ≤60 years. Patients with r/r B-NHL: 18 years old ≤ patient age ≤65 years old 7. Hematological indicators meet the following conditions: 1) WBC count ≥ 1.5× 10\^9/L; 2) Absolute value of neutrophils ≥ 0.8× 10\^9/L; 3) Lymphocyte count ≥ 0.1× 10\^9/L; 4) Hemoglobin ≥ 60 g/L; 5) Platelet count ≥ 20× 10\^9/L; 8. Blood biochemistry shall meet the following requirements 1) or 2): 1) patients with liver and kidney without tumor lesions: A) Total bilirubin (TBIL)≤1.5\*ULN (upper limit of normal value), unless suffering from Gilbert's syndrome; B) aspartate aminotransferase (AST) ≤ 1.5 \* ULN; C) ALT ≤ 1.5 \* ULN; D) Scr ≤ 1.5 \* ULN; E) Urea (URA) ≤ 1.5 \* ULN; 2) patients with liver and kidney tumor lesions: a) TBIL≤5\*ULN； b) AST≤5\*ULN； c) ALT≤5\*ULN； d) SCr≤5\*ULN； e) Urea≤5\*ULN； 9. Heart function: good hemodynamic stability, and the left ventricular ejection fraction (LVEF) is higher than or equal to 55%; 10. Serum viruses such as HIV, TP, HBV(HBV-DNA) and HCV(HCV-DNA) are all negative; 11. ECOG activity status score: 0-2 points; 12. Accept the requirement that effective contraception be used throughout the study; 13. Willing to abide by the rules established in this study. Exclusion Criteria: 1. Pregnant or lactating women; 2. Having a pregnancy plan in the next two years; 3. Has received graft-versus-host disease treatment in the past; 4. Has received allogeneic cell therapy in the past 6 weeks; 5. Has received allogeneic stem cell transplantation within the past 6 months; 6. Individual extramedullary relapse B-ALL; 7. Suffering from severe mental disorder; 8. Active autoimmune diseases requiring immunotherapy; 9. Has suffered from other malignant tumors in the past; 10. Patients with severe cardiovascular disease; 11. Prothrombin time or activated partial thromboplastin time or international normalized ratio \> \>1.5\*ULN； in the absence of anticoagulant therapy; 12. There is active infectious disease or need any major infection events of high-level antibiotics; 13. Any condition that, in the opinion of the investigator, may increase the subject's risk or interfere with the study results.