Early Bactericidal Activity, Safety & Tolerability of Oral GSK3036656 in a Dual Combination With Novel and Established Antitubercular Agents, or Standard of Care in Adults With Rifampicin Susceptible Pulmonary Tuberculosis

GlaxoSmithKline127 enrolled

Overview

This study measured the early bactericidal activity (EBA), safety, tolerability and pharmacokinetics of GSK3036656 in combination with either delamanid, bedaquiline or BTZ-043 and delamanid in combination with bedaquiline or standard of care, for 14 days, in participants with newly diagnosed sputum smear positive drug-sensitive pulmonary tuberculosis. Participants reverted to the standard treatment (RIFAFOUR e-275) once the study treatment (Day 1 to Day 14) was completed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

127

Conditions

Tuberculosis

Interventions

GSK3036656DRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Participants were 18 to 65 years of age inclusive, at the time of signing the informed consent. * Participants had: 1. A new episode of untreated, rifampicin-susceptible pulmonary tuberculosis (TB) 2. A chest X-ray picture consistent with pulmonary TB 3. At least one sputum sample positive on direct microscopy for acid-fast bacilli (at least 1+ on the International Union Against Tuberculosis and Lung Disease \[IUATLD\]/World Health Organization \[WHO\] scale) or positive on a molecular test (at least medium positive for MTB on Xpert MTB/Rif) 4. A normal echocardiogram, or an echocardiogram with normal left ventricular function with at most trace to mild valvular regurgitation, and no valvular stenosis 5. A creatinine clearance greater than or equal to (\>=) 90 mL/minute (Cockcroft-Gault formula) * Male participants were eligible to participate if they agreed to barrier precautions until 90 days after the last dose. * A female participant was eligible to participate if she was not pregnant or breastfeeding and was a woman of non-childbearing potential (WONCBP) or a woman of childbearing potential (WOCBP) using a highly effective contraceptive method. A WOCBP had to have a negative urine or serum pregnancy test, as required by local regulations, before the first dose of study intervention. Only participants who were at least 25 years of age, and females of non-childbearing potential, were eligible for the positron emission tomography-computed tomography (PET-CT) assessments. * Participants were capable of giving signed informed consent. Exclusion Criteria: * There was evidence of a clinically significant condition or abnormality (as judged by the Investigator) (other than the indication being studied) that might have compromised safety or the interpretation of trial efficacy or safety endpoints. * There was clinically significant evidence of extrathoracic TB, as judged by the Investigator. * QTc interval corrected for heart rate by Fridericia's formula (QTcF) was greater than (\>) 450 milliseconds (msec). * There was arterial hypertension with systolic BP \>=160 mm Hg or diastolic BP \>=100 mm Hg. Participants with well-controlled hypertension could be included if they were using amlodipine for the duration of the study. * Participants had vitiligo. * Participants were receiving QT-prolonging drugs, including but not limited to fluoroquinolones, macrolides, and clofazimine. * HIV-infected participants who: 1. had a cluster of differentiation (CD)4+ count \<350 cells/microliters; 2. had received antiretroviral therapy medication within the last 30 days; 3. had received oral or intravenous antifungal medication within the last 30 days; 4. or had an acquired immunodeficiency syndrome (AIDS)-defining opportunistic infection or malignancy in the last 12 months (except pulmonary TB). * Hepatitis B surface antigen (HBsAg) was present, or the Hepatitis C antibody test result at screening was positive. * Participants had diabetes (Type 1 or 2), point-of-care glycated hemoglobin (HbA1c) above 6.5%, or random glucose over 11.1 millimoles (mmol)/L. * There were diseases or conditions in which the use of delamanid or bedaquiline was contraindicated. * Participants had abnormal laboratory values at screening, as graded by the enhanced Common Terminology Criteria for Adverse Events (CTCAE version 5, 2017).

Outcomes

Primary Outcomes

Change From Baseline in log10 Colony Forming Units (CFU) of Mycobacterium Tuberculosis (MTB)

Baseline was defined as the mean of Day -2 and Day -1. If data was available at only one of these timepoints, then that value was used as baseline.

Time frame: At Baseline and at days 1, 2, 3, 4, 6, 8, 10, 12 and 14

Secondary Outcomes

Change From Baseline in Time to Sputum Culture Positivity

Baseline was defined as the mean of Day -2 and Day -1. If data was available at only one of these timepoints, then that value was used as baseline.

Time frame: At Baseline and at days 1, 2, 3, 4, 6, 8, 10, 12 and 14

Number of Participants With Serious Adverse Events (SAEs)

An SAE was defined as any untoward medical occurrence that, at any dose, resulted in death, was life-threatening, required hospitalization or prolongation of existing hospitalization, resulted in disability/incapacity, caused a congenital anomaly/birth defect, or was any other situation identified according to medical or scientific judgment.