A pharmacoimaging study of oxytcoin in antisocial personality disorder and psychopathy
Using a double-blinded, placebo controlled design, we explored similarities and differences in i) an important component of empathic processing (neural response to facial emotional expressions) and ii) decision-making in violent men with ASPD+/-Psychopathy, compared to healthy non-offenders (NO; n= 21 across studies), with placebo and after acute application of intranasal oxytocin, using functional Magnetic Resonance Imaging (fMRI).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
72
Intranasal spray containing 40 IU of oxytocin
Application of inert placebo, identical in odor, color, and droplet size except for absence of oxytocin
Insititue of Psychiarty, Psychology and Neuroscience
London, Nottinghamshire, United Kingdom
Within-group effect of oxytocin on nerual modulation of fear
Differences in responsivity to morphed faces on FMRI in oxytocin vs fear condition- clusterwise analysis using AFNI (effect size is beta values)
Time frame: 10 minutes
Baseline neural modulation of morphed fearful faces
Response to morphred faces on FMRI in placebo condition- clusterwise analysis using AFNI (effect size is beta values)
Time frame: 10 minutes
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