In patients undergoing cardiac surgery, perioperative anemia is an important factor in surgical recovery. In addition to the low preoperative hemoglobin level, the delayed recovery of the postoperative hemoglobin level is an important problem affecting the incidence of postoperative anemia. Erythroferron is the early response to of the red blood cell production in stressful situations such as anemia, bleeding, and hypoxia. Therefore, it is thought that acute blood loss and systemic inflammatory reaction that inevitably occurs after cardiac surgery will synthesize erythroferron, which helps to restore hemoglobin level at postoperative period by promoting hematopoiesis by simultaneously inhibiting hepcidin and activating hematopoiesis. In this study, the investigators will investigate the association between Erythroferron and perioperative hemoglobin levels in patient undergoing heart valve surgery.
Study Type
OBSERVATIONAL
Enrollment
150
Yonsei University Health System, Severance Hospital
Seoul, South Korea
Change of hemoglobin concentration level after surgery in patients undergoing heart valve surgery
Compare the change of hemoglobin concentration level after surgery in patients undergoing heart valve surgery, by dividing the groups according to the level of erythroferron immediately after surgery. The amount of change will be compared based on the lowest level of hemoglobin during the time point after surgery. Since investigators planed to compare the recovery rate as well as the amount of recovery at each time point, investigators planed to record the change of hemoglobin at each time point based on the lowest hemoglobin level after surgery.
Time frame: immediate after surgery, POD1, POD2, POD7, first outpatient vist after discharge (until 6 months)
Change in serum erythropoietin (EPO) level
Serum erythropoietin concentration will be measured using a quantitative ELISA assay and reported as mIU/mL. Changes in EPO level from baseline to 6 months will be compared among ERFE tertile groups.
Time frame: From baseline (preoperative) to 6 months postoperatively
Change in serum hepcidin level
Serum hepcidin concentration will be measured using liquid chromatography-mass spectrometry (LC-MS) and reported as ng/mL.
Time frame: From baseline (preoperative) to 6 months postoperatively
Change in hemoglobin (Hb) concentration
Hemoglobin will be measured using an automated hematology analyzer and reported as g/dL.
Time frame: From baseline (preoperative) to 6 months postoperatively
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