Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer

Inclusion Criteria: 1. Age ≥18 years old, gender unlimited; 2. A clear diagnosis of leptomeningeal metastases derived from lung cancer , including positive cerebrospinal fluid cytology and/or neuroimaging diagnosis; 3. A clear history of lung cancer, including histopathological diagnosis, or a combination of cytopathology and imaging; 4. Proper organ function (neutrophil count ≥1.5× 109 /L, platelet count ≥100× 109 /L, hemoglobin concentration ≥90g/L, serum transaminase concentration ≤2.5 times the limit of normal value, serum creatinine concentration ≤ 1.5 times the upper limit of normal value, proteinuria ≤1+) 5. Dexamethasone ≤2 mg (or equivalent) 7 days before the start of treatment in patients requiring long-term use of the hormone 6. Signed the informed consent and was willing to follow the experimental protocol and follow-up Exclusion Criteria: 1. Patients with positive driver genes and effective treatment, such as patients with positive EGFR gene sensitive mutation 2. Severe infections or serious comorbidities, such as hemorrhagic peptic ulcer, intestinal obstruction, heart failure, kidney failure, or poorly controlled diabetes; 3. Be allergic to PD-1 inhibitor and recombinant human endostatin 4. The female patient planned to be pregnant, was pregnant and lactating -