With the change in environment and lifestyle, and the improvement of people's understanding of PCOS, the incidence of PCOS is increasing worldwide. According to statistics, the prevalence of PCOS in premenopausal women is as high as 5-20%. Lifestyle interventions are the main treatment option for patients with PCOS. In addition, research has shown that digital therapy can effectively improve behavior changes in diet, exercise, and medication adherence, predict disease progression, reduce the frequency of disease-related symptoms, and promote effective disease management. This study aimed to investigate the efficacy of digital intervention versus traditional metformin monotherapy in patients with PCOS.
This study developed a mini-program that combined diet, exercise, sleep, and mood interventions for PCOS women.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
This study developed a mini-program that combined diet, exercise, sleep, and mood interventions for PCOS women.
Traditional metformin monotherapy.
Department of Endocrinology, Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China
Homeostasis model assessment of insulin resistance
insulin resistance index
Time frame: 3 months
Anthropometry
body mass index (kg/m2)
Time frame: 3 months
menstrual frequency
number of menstruation in a year
Time frame: 3 months
fasting glucose
fasting glucose（mmol/L)
Time frame: 3 months
fasting insulin
fasting insulin（mmol/L)
Time frame: 3 months
Total cholesterol
Total cholesterol (mmol/L)
Time frame: 3 months
Triglycerides
Triglycerides (mmol/L)
Time frame: 3 months
HDL-c
HDL-c (mmol/L)
Time frame: 3 months
LDL-c
LDL-c (mmol/L)
Time frame: 3 months
total testosterone
total testosterone (nmol/L)
Time frame: 3 months
free testosterone
free testosterone (nmol/L)
Time frame: 3 months
Sex hormone-binding globulin
Sex hormone-binding globulin (nmol/L)
Time frame: 3 months
Androstenedione
Androstenedione (ng/ml)
Time frame: 3 months
Dehydroepiandrosterone
Dehydroepiandrosterone (ug/dl)
Time frame: 3 months
International Physical Activity Questionnaire (IPAQ)
Assess physical activity situation in women with PCOS.
Time frame: 3 months
Pittsburgh Sleep Quality Index (PSQI)
Assess sleep situation in women with PCOS.
Time frame: 3 months
Hospital Anxiety and Depression Scale (HADS)
To evaluate anxiety and depression in PCOS women.
Time frame: 3 months
Three-Factor Eating Questionnaire (TFEQ-R21)
Assess eating behavior in women with PCOS.
Time frame: 3 months
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