The Radiologically Isolated Syndrome (RIS) is defined as incidental Magnetic Resonance Imaging (MRI) abnormalities fulfil the criteria for dissemination in space, suggestive of multiple sclerosis. Nowadays, mandatory vaccination in patients with multiple sclerosis (MS) is widely recommended. Regarding COVID19, the absence of specific warnings led to the proposal of vaccination in patients with inflammatory diseases of the central nervous system. We aimed to evaluate if COVID19 vaccination or infection increased the risk of clinical conversion to multiple sclerosis or evidence of disease activity (EDA) in a cohort of RIS subjects.
Study Type
OBSERVATIONAL
Enrollment
217
no intervention
Nice University Hospital
Nice, France
COVID 19 vaccination and clinical conversion to multiple sclerosis risk
number of patients with a conversion to MS in each group
Time frame: year 2
COVID 19 vaccination and evidence disease activity risk
number of patients with an evidence disease activity in each group
Time frame: year 2
multiple sclerosis evolution and history of COVID 19 infection
number of patients with a conversion to MS in each group
Time frame: year 2
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