Cefuroxime is a time-dependent antibiotic that is used to treat bacterial infections. However, population pharmacokinetic，effectiveness and safety data for cefuroxime in neonates are lacking. The aim of this study was to assess the population pharmacokinetics, effectiveness, and safety of cefuroxime in neonates.
Study Type
OBSERVATIONAL
Enrollment
100
Population pharmacokinetics, effectiveness, and safety of cefuroxime
Tianjin Central Hospital of Gynecology Obstetrics
Tianjin, Tianjin Municipality, China
RECRUITINGThe peak plasma drug concentration of cefuroxime
To detect the peak plasma drug concentration of cefuroxime after intravenous administration.
Time frame: at (5-10) minutes after intravenous administration
The random plasma drug concentration of cefuroxime
To detect the random plasma drug concentration of cefuroxime after intravenous administration.
Time frame: at (0.25-10) hours after intravenous administration.
The trough plasma drug concentration of cefuroxime
To detect the trough plasma drug concentration of cefuroxime after intravenous administration.
Time frame: at 1-2 hours before the next administration
The time of free drug concentration exceeding the minimal inhibitory concentration (fT>MIC)
PD target
Time frame: Through study completion, an average of 3 days
Adverse events
Drug-related adverse events and serious adverse events
Time frame: Through study completion, an average of 15 days
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