A Study to Assess the Safety and Pharmacokinetics of Single Ascending Subcutaneous and Intravenous Doses of DS-2325a in Healthy Subjects

Inclusion Criteria: * Participants must give written informed consent to participation in the study prior to Screening * Healthy men and women 18 to 45 years of age (inclusive), with a BMI of 18 kg/m2 to 30 kg/m\^2 (inclusive) at Screening * All women must have a negative serum pregnancy test at Screening and all women of childbearing potential must have a negative urine pregnancy test on Day -1 * Women must not be lactating during the study treatment period and for 3 months after the last dose of study treatment * Women of childbearing potential must practice effective contraception during the study treatment period and for 3 months after the last dose of study treatment. They must agree to use 2 different means of nonhormonal contraceptive methods * Women of non-childbearing potential must be either surgically sterile (ie, bilateral tubal ligation at least 3 months prior to dosing) or in menopausal state confirmed as follows: 1 year of spontaneous amenorrhea without an alternative medical cause and a serum FSH level ≥40 mIU/mL * Men must agree to use contraception (condom with spermicide) during the study treatment period and for at least 3 months after the last dose of study treatment or be surgically sterile (vasectomy at least 3 months prior to dosing) * Women should not donate eggs and men should not donate sperm during the study treatment period and for at least 3 months after the last dose of study treatment * Participants must be in good health as determined by Screening medical history, physical examination, vital signs, ECGs, serum chemistry, hematology, virology, and urinalysis performed at Screening and on Day -1 Exclusion Criteria: * History or current chronic lung disease including asthma, chronic obstructive pulmonary disease (COPD), or heavy smoking of \>10 pack years * Previous or current treatment with systemic corticosteroids or any immunosuppressive agents * Participants who have received a transfusion or any blood products within the last year prior to dosing * Participants who have made any blood donation or have had a loss of blood of ≥500 mL within 56 days prior to the dose of study drug * Participants who consume more than 21 units of alcohol per week (1 unit of alcohol equals 1/2 pint of beer, 4 ounces of wine, or 1 ounce of spirits) or those participants who have a significant history of alcoholism or drug/chemical abuse within the last 2 years. * Participants with positive results on tests for drugs of abuse, cotinine, or alcohol at Screening and/or Day -1.