Injectable Platelet Rich Fibrin With Collagen Matrix in Treatment of Multiple Gingival Recession.

University of Baghdad20 enrolled

Overview

This study is proposing the use of i-PRF clot as a scaffold for the XCM in order to obtain a novel biomaterial, incorporating active growth factors and collagen matrix in a single framework, based on the potential effect of i-PRF to enhance fibroblast activity and angiogenesis stimulation for treatment of multiple gingival recession.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Gingival Diseases Traumatic Injury

Interventions

CAF+CMPROCEDURE

Periodontal surgery including CAF+CM application

I-PRFPROCEDURE

Periodontal surgery including CAF+CM application with i-PRF

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of at least two localized gingival recessions on either sides of the maxilla and/or mandible excluding molar region. * The cemento-enamel junction (CEJ) is visible in the teeth for root coverage procedures. * All recessions are type 1recession RT1 (cairo et al,2011) which correspond to Miller I\&II gingival recession * All patients must demonstrate adequate plaque control with a fullmouth plaque score less than 20% and with . * All patients at least 18 years of age and of both genders. Exclusion Criteria: * Smoker Patients . * Patients with diabetes. * Patients with a history of malignancy, radiotherapy, or chemotherapy for malignancy. * pregnant or nursing women. * Patients taking medications or having treatments with an effect on mucosal healing in general (e.g. steroids, large doses of antiinflammatory drugs). * Patients with a disease affecting connective tissue metabolism. * Patients allergic to collagen.

Locations (1)

University of Baghdad / College of Dentistry

Baghdad, Iraq

Outcomes

Primary Outcomes

Reduction in gingival recession depth on the buccal sides of type one gingival recessionRT1

The primary outcome of the study is the reduction in gingival recession depth on the buccal sides of RT1 gingival recession, between the baseline preoperative measurement and follow-up at 3 months and 6 months. The Recession Depth (RD) is Measured in millimeter (mm) from CEJ (Cemento-Enamel-Junction) to the gingival margin using UNC-15 probe.