OsciPulse D-dimer Efficacy Trial

Inclusion Criteria: 1. Adult aged ≥ 18 years old 2. Admitted to the Neuro Intensive Care Unit or Intermediate Neuro Care Unit with a diagnosis of ischemic stroke 3. Last known normal \< 24 hours. 4. NIH stroke score ≥5 5. Weakness in at least one leg (≥ 1 point on the NIHSS lower extremity motor scores, items 6A and 6B) 6. Prescribed mechanical therapy for DVT prophylaxis. Exclusion Criteria: 1. Inability or contraindication to applying IPC to both legs such as: * Evidence of bone fracture in lower extremities * Burns in the lower extremities, lacerations, ulcers, active skin infection or dermatitis, * ischemic limb in the legs at the site of IPC placement * Acute ischemia in the lower extremities * Severe peripheral vascular disease * Amputated foot or leg on one or two sides * Compartment syndrome * Severe lower extremity edema * Acute deep vein thrombosis 2. Subjects who received tPA therapy for their stroke 3. Pregnancy or within 6 weeks of postpartum period 4. Limitation of life support, life expectancy \< 7 days, or in hospice care 5. A head-unit is unavailable for the first 24 hours or more 6. At the discretion of the attending physician and / or clinical team, the subject's participation in the study is believed not to be in the best interest of the subject.