Diabetes, Falls, and Fractures

Aalborg University Hospital110 enrolled

Overview

Comparing severity of diabetic peripheral neuropathy (small and large fibers including autonomic neuroapthy) to postural control and vestibular measurements

Study Type

OBSERVATIONAL

Enrollment

110

Conditions

Diabetic Peripheral Neuropathy Diabetes Balance; Distorted Vestibular Neuropathy Muscle Weakness Sarcopenia Autonomic Neuropathy, Diabetic Small Fiber Neuropathy

Interventions

Quantative Sensory TestingDIAGNOSTIC_TEST

Evaluation of small fiber neuropathy

NCStat-DPN-CheckDIAGNOSTIC_TEST

Evaluation of large fiber neuropathy

Composite Autonomic Symptom Score 31DIAGNOSTIC_TEST

Evaluation of autonomic neuropathy

Eligibility

Sex: ALLMin age: 40 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Men and women with minimum 40 years of age and maximum 70 years of age. 2. Diagnosis of T1D or T2D 3. Diagnosis of diabetes with at least one year prior to inclusion of the study 4. Signed the informed consent. Exclusion Criteria: 1. Severe decreased liver function (Alanin amino-transaminase (ALAT)\>250u/l, GammaGlutamyltransferase (GGT)\>150u/l) 2. Moderate to severe kidney dysfunction, estimated Glomerular Filtration Rate (eGFR) \<15mmol/L/1,73m2 3. Pregnancy or breast feeding 4. Active malignancy or terminal ill. 5. Current or previous alcohol- or drug abuse 8\. Not being able to understand Danish written and/or verbally 9. Terms according to investigators judgement that makes subjects unsuitable to participate including lack of understanding or reduced physical ability. 10. Participating in other clinical studies 11. Maximum of 10 hours of weekly exercise.

Locations (1)

Aalborg University Hospital

Aalborg, Denmark

Outcomes

Primary Outcomes

Co-existence of peripheral- and vestiubular neuropathy in people with diabetes

Vestibular neuropathy (measured by pathological video head impulse test (v-Hit) (one-sided, two-sided or specific arcways)) will be compared with peripheral neuropathy (measured by quantitative sensory testing, nerve conduction and COMPASS-33) in the population with diabetes.