Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia

Sedation

Using the eight-point Modified Ramsay Sedation Score: 1. Awake and alert, minimal or no cognitive impairment. 2. Awake but tranquil, purposeful responses to verbal commands at a conversational level. 3. Appears asleep, purposeful response to verbal commands at a conversational level. 4. Appears asleep, purposeful responses to commands but at a louder than conversational level, requiring light glabellar tap, or both. 5. Asleep, sluggish purposeful responses only to loud verbal commands, strong glabellar tap, or both. 6. Asleep, sluggish purposeful responses only to painful stimuli. 7. Asleep, reflex withdrawal to painful stimuli only 8. Unresponsive to external stimuli, including pain

Time frame: 30 minutes preoperative, at 0 hour postoperative, at 1 hour postoperative 4, at 8 hour postoperative.

Heart rate

it will be measured by pulse oximeter and expressed as beats per minute.

Time frame: 30 minutes preoperative, at 0 hour postoperative, at 1 hour postoperative 4, at 8 hour postoperative.

Respiratory rate

it will be measured by counting the number of breaths for one minute by counting how many times the chest rises and expressed as breaths per minute.

Time frame: 30 minutes preoperative, at 0 hour postoperative, at 1 hour postoperative 4, at 8 hour postoperative.

Temperature

it will be measured by thermometer and expressed in degrees Celsius ( °C ).

Time frame: 30 minutes preoperative, at 0 hour postoperative, at 1 hour postoperative 4, at 8 hour postoperative.

Blood pressure

Systolic and diastolic blood pressure will be measured by sphygmomanometer and expressed in millimeters of mercury (mmHg).

Time frame: 30 minutes preoperative, at 0 hour postoperative, at 1 hour postoperative 4, at 8 hour postoperative.

O2 saturation

it will be measured by pulse oximeter and expressed as percent (%).

Time frame: 30 minutes preoperative, at 0 hour postoperative, at 1 hour postoperative 4, at 8 hour postoperative.

Drug side effects

Measuring the incidence of undesirable effect of a drug (constipation, respiratory depression, diarrhea, headache, dyspepsia, itching, urinary retention, and pruritus) using a questionnaire with Yes or No answer.

Time frame: at 0 hour postoperative, at 1 hour postoperative 4, at 8 hour postoperative.

Postoperative nausea and vomiting

Postoperative nausea and vomiting intensity scale Q1 Have you vomited or had dry-retching? 1. No(0-Score) 2. Once or twice(2-Score) 3. Three or more times(50-Score) Q2 Have you experienced a feeling of nausea (an unsettled feeling in the stomach and slight urge to vomit)? If yes. has your feeling of nausea interfered with activities of daily living? such as being able to get out of bed, being able to move about freely in bed, being able to walk normally or eating and drinking? a) No(0-Score) b) Sometimes(1-Score) c) Often or most of the time(2-Score) d) All of the time(25-Score) Q3 Has your nausea been mostly: 1. varying?(1-Score) 2. constant?(2-Score) Q4 What was the duration of your feeling of nausea(in hours)? Where a score ≥50 defined clinically important PONV: PONV Intensity Scale=severity of nausea (1=mild, 2=moderate, 3=severe) × pattern of nausea (1=varying, 2=constant) × duration of nausea (in hours)

Time frame: At 6 hour postoperative

Rescue analgesia

Time to first use of rescue analgesia (which is 3 my IV Morphine) and Total analgesic consumption (mg/kg)

Time frame: at 0 hour postoperative, at 1 hour postoperative 4, at 8 hour postoperative.

Antiemetics

Time to first use of antiemetics (which is 4 mg IV Ondansetrone) and Total analgesic consumption (mg/kg)

Time frame: at 0 hour postoperative, at 1 hour postoperative 4, at 8 hour postoperative.