Preoperative Level of Hemoglobin A1c and Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery

Ain Shams University40 enrolled

Overview

Background: The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. This study will investigate the association of preoperative HbA1c levels with AKI after isolated coronary artery bypass grafting (CABG).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Kidney Injury

Interventions

increase in serum creatinineDIAGNOSTIC_TEST

any of the following: increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinin

Eligibility

Sex: ALLMin age: 45 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA physical status II-III * scheduled to undergo isolated coronary artery bypass grafting Exclusion Criteria: * Patients with history of renal failure * Patients with history of hepatic failure * Patients with history of heart failure * previous cardiac surgery * cerebrovascular event in the last 30 days * percutaneous coronary intervention in the last 30 days prior to operation * peripheral arterial disease * malignancy * infectious diseases * patients who required surgical revision * patients who required postoperative intra-aortic balloon pump * patients with CBP time \> 120 min or aortic cross clamp time \> 90 min

Locations (1)

Ain-Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

serum creatinine level

increase in serum creatinine by ≥ 0.3 mg/dl within 48 h of surgery or increase in serum creatinine to ≥ 1.5 times baseline within 3 days of cardiac surgery

Time frame: 3 days

Secondary Outcomes

Patients in need of RRT

The number of patients requiring postoperative renal replacement therapy

Time frame: 7 days

Data from ClinicalTrials.gov

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