The Effect of Solifenacin Used for Lower Urinary Tract Symptoms on Sexual Function

Istanbul University150 enrolled

Overview

This study aims to determine whether Solifenacine used for lower urinary tract symptoms improves sexual function and if so does this improvement differs between premenopausal and postmenopausal women.

Solifenacin is an anticholinergic drug that is commonly used for lower urinary tract symptoms such as urgency, frequency and urge urinary incontinence. Solifenacin use and sexual function improvement is presented in some research, but the correlation between the improvement in sexual function and LUTS symptoms is yet not investigated. Also the effect on sexual function in premenopausal vs postmenopausal women are unknown.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Urge Incontinence Urgency-frequency Syndrome

Interventions

no interventionOTHER

no intervention planned, since it is an observational study

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women presented in Arnavutkoy State Hospital Gynecology Clinic with lower urinary tract symptoms that are planned to start treatment with Solifenacin 5 mg (Vesicare 5mg). * Patients agreed to involve in the study, having discussed other treatment options and possible side effects of the medication. * Informed consent obtained Exclusion Criteria: * urinary tract infection * stress urinary incontinence * urinary retention * grade 2 or above pelvic organ prolapse according to POP-Q scale * Solifenacin contraindications such as narrow angle glaucoma, allergy of Solifenacin or other components of the drug.

Locations (1)

Arnavutkoy State Hospital

Istanbul, Arnavutkoy, Turkey (Türkiye)

RECRUITING

Outcomes

Primary Outcomes

the effect of solifenasin used for lower urinary tract symptoms on sexual function

Female Sexual Function Index (FSFI) scores change between in baseline, 3 and 6 months after Solifenacin use for lower urinary tract symptoms.

Time frame: 6 months

the effect of solifenasin used for lower urinary tract symptoms on sexual function in premenapausal vs postmenapausal women

The aim of this study is to determine whether Solifenacine used for lower urinary tract symptoms improve sexual function (measured by Female Sexual Function Index; higher scores meaning sexual dysfunction with the cut off value of 26.) and if so does this improvement differs between premenaupausal and postmenaupausal women.

Time frame: 6 months

Secondary Outcomes

the effect of Solifenacin treatment for lower urinary tract symptoms (LUTS) on sexual function and its correleation with the improvement in LUTS

The aim of this study is to determine whether Solifenacine used for lower urinary tract symptoms improve sexual function (measured by Female Sexual Function Index; higher scores meaning sexual dysfunction with the cut off value 26.)and if so does this correlates with the improvement with lower urinary tract disorders.

Time frame: 3 and 6 months

Central Contacts

Inci Sema Tas, MD

CONTACT

00905359509232 incisematas@gmail.com

Data from ClinicalTrials.gov

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