Pharmacodynamics of Injection of Cisatracurium Base on Lean Body Mass Pattern to Maintain Deep Neuromuscular Blockade in Obese Patients

Change in average dosing interval time

PTC(post-tetanic count)was measured every 6min during the operation, and cisatracurium was injected once when PTC \> 2,average dosing interval time was recorded

Time frame: during the surgery

Change in Times of adding cisatracurium

PTC was measured every 6min during the operation, and cisatracurium was injected once when PTC \> 2,and recording the total times of injection.

Time frame: during the surgery

Change in total dosage of cisatracurium

PTC(post-tetanic count) was measured every 6min during the operation, and cisatracurium was injected once when PTC \> 2,and recording the total dosage of total dosage of cisatracurium

Time frame: during the surgery

Change in time of onset

0.15mg/kg (3ED95) cisatracurium was given to all groups according to actual body weight as induction dose. Tracheal intubation was performed in all groups when TOFr(train of four ratio)=0.recording the time during this process.

Time frame: through study completion, an average of 3 minute after induction

Change in TOF(train of four) recovered to 0.7 and 0.9 from the last injection

The recovery of TOF(train of four) was continue observed after surgery.Recording the time both when TOF(train of four) recovered to 0.7 and 0.9

Time frame: up to 1 hour after the surgery

Change in time during PACU(postanesthesia care unit)

recoding the duration of stay in PACU(postanesthesia care unit)

Time frame: up to 2 hour after the surgery

surgical rating scale(SRS)

Surgical rating Scale (SRS) was evaluated by surgical surgeons at the beginning, 1h and 2h of surgery, with a range of 1 to 5, corresponding to "extremely poor", "poor", "adequate", "good" and "best".