The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS). In this case, very few studies have investigated changes in gas exchange during COVID-19 progression in spontaneously breathing patients. The investigators purpose in this study to explore the pathophysiology of gas exchange and time course changes in spontaneously breathing patients with acute respiratory failure due to COVID-19. Moreover, our aim is to identify early markers associated with worsening respiratory failure and requiring endotracheal intubation.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
59
Exploration of pathophysiology of gas exchange
Damien JOLLY
Reims, France
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and need to intubation.
From date of admission in intensive care unit (ICU) until the date of death or disharge from ICU, assessed up to 90 days
Time frame: Lenght of hospital stay in intensive care unit
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D90.
No provided
Time frame: Day 90
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D28.
No provided
Time frame: Day 28
Association between intrapulmonary right-to-left shunt, ventilatory ratio with percentage of lung damage on chest CT-scan.
No provided
Time frame: At admission
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