Multicentral Preventive Antibiotics With Cystectomy Within Enhanced Recovery After Surgery

Inclusion Criteria: * histologically confirmed diagnosis of very high risk non muscle-invasive bladder carcinoma (cT1NoMo) or muscle-invasive bladder carcinoma (cT2-T4NxM0) with or without neoadjuvant therapy (chemotherapy or immunotherapy are both possible); * patient should be eligible for radical cystectomy (RC) + pelvic lymph node dissection (PLND), and agreement to undergo curative intent standard RC + PLND (including prostatectomy or hysterectomy if applicable) according to surgeon opinion; * pelvic lymph node dissection is engaged in two possible variants: extended level to intersection of ureter and iliac vessels; superextended level - up to aortic bifurcation; * urinary diversion is engaged in two possible variants: orthotopic diversion (J- or U-pouch reservoirs), heterotopic diversion in the Mainz-I modification, Bricker; * male or female is at least 18 years old at the time of signing the informed consent form; * female patient is eligible to participate if she is not pregnant, not breastfeeding; * ECOG performance status of 0 or 1; * adequate organ function (in accordance with laboratory standards); * used valid protocol for Enhanced Recovery After Surgery (ERAS protocol) at Hospital (oncourological department); Exclusion Criteria: * known additional non-urothelial malignancy that is progressing or has required active anticancer treatment ≤3 years of study randomization, with certain exceptions; * diagnosis of immunodeficiency or receipt of chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior the first dose of study drug; * replacement doses of corticosteroids are permitted for participants with adrenal insufficiency; * evidences of uncontrolled diseases (diabetes mellites, noninfectious pneumonitis that required steroids, et.) or any conditions which interfere with the conduct of the research procedures according to doctor opinion; * presence of 2 or more criteria for systemic inflammatory response syndrome (SIRS) at the time of the patient's admission to the hospital (assessment of these factors 3-7 days before randomization): * temperature ≥ 38˚С or ≤ 36˚С; * heart rate (HR) ≥ 90 / min; * respiratory rate \< 20/min or hyperventilation (Pa CO2 ≤ 32 mm Hg); * blood leukocytes \>12 ∙ 109 / l or \< 4 ∙ 109 / l, or immature forms \> 10% * prohibited urinary diversion when planning surgery and signing voluntary consent: diversion into continuous intestine (ureterosigmostomy, Mainz-pouch II operation); * inadequate organ function: * Neutrophils \<1.5 x 10 \^ 9 / l * Platelets \<100 x 10 \^ 9 / l * ALT\> 3 x VGN * AST\> 3 x VGN * Bilirubin\> 1.5 x ULN * GFR level \<35 ml / min