A methanol extract of Corchorus olitorius edible plant was perpared for extration of glycosideal compounds. the extract was tested for its efficacy as antiinflammatory and analgesic activity invitro and approved by the biomarkers. a fast dissolvinf mucoadhesive film was prepared by a certain amounts of highly safe polymers for a pilote study on human for treament of Aphthous Ulcerations. two groups of study, placebo and intrvention will be recurited and followed for pain, erthymia and size of ulcers for 6 days.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
20
Corchorus Olitorius Buccal fast dissolving Films
plain mucoadhesive fast dissolving film
Minya university, faculty of medicin
Minya, Minya Governorate, Egypt
treatment of ulcer
ulcer size by the investigator, the diameter measured as the distance between two oppisit points of the wight area of ulcer
Time frame: 6 days
Pain scoring
pain measured by VAS tool, 0 the least pain while 10 the highest one
Time frame: 6 days
Erthymia
Erthymia estimated by the dgree of redness by the investgator, the darkest indicadetes the worst one
Time frame: 6 days
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