Patients with Acute on Chronic Liver Failure (ACLF) have high short-term mortality. The use of a severity score could define the patient's prognosis. This study mainly prospectively analyze the clinical data of patients with chronic liver disease related acute liver failure admitted to the department of infectious diseases, Xiangya Hospital of Central South University, to analyze the prognosis of patients with chronic liver disease related acute on-chronic liver failure in Central South China. No additional interventions other than routine treatment will be added.
Patients with Acute on Chronic Liver Failure (ACLF) have high short-term mortality. The use of a severity score could define the patient's prognosis and would help determine in whom the treatment is effective. This study mainly prospectively analyze the clinical data of patients with chronic liver disease related acute liver failure admitted to the department of infectious diseases, Xiangya Hospital of Central South University, to analyze the short-time and relatively long-term prognosis of patients with chronic liver disease related acute on-chronic liver failure. This is an observational study. All subjects will receive the currently recognized routine treatment of liver failure and corresponding etiological treatment if needed. The researchers will collect various clinical examination indexes of the subjects in the process of diagnosis and treatment, including but not limited to blood routine, biochemistry, coagulation function, liver imaging, therapeutic drugs, etc. Complications and prognosis of patients will be recorded. Blood samples, urine and stool samples of all subjects will be taken after enrollment and stored for probably testing in the future. This study has no additional intervention and treatment for subjects. All subjects will sign informed consent.
Study Type
OBSERVATIONAL
Enrollment
500
Xiangya Hospital
Changsha, Hunan, China
RECRUITINGNon-liver transplant mortality
short time mortality
Time frame: 15 days
Non-liver transplant mortality
short time mortality
Time frame: 30 days
Non-liver transplant mortality
short time mortality
Time frame: 90 days
Non-liver transplant mortality
long time mortality
Time frame: 12 months
Non-liver transplant mortality
long time mortality
Time frame: 36 months
Liver transplantation rate
mortality of all patients including those receiving liver transplantation
Time frame: 1 month
Liver transplantation rate
mortality of all patients including those receiving liver transplantation
Time frame: 6 months
Liver transplantation rate
mortality of all patients including those receiving liver transplantation
Time frame: 12 months
Model for disease severity
MELD score will be calculated and reported
Time frame: 1 month
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Model for disease severity
MELD score will be calculated and reported
Time frame: 6 months
Model for disease severity
MELD score will be calculated and reported
Time frame: 12 months