Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy

Centre Hospitalier Universitaire de Nīmes111 enrolled

Overview

Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging (SWI) in the majority of patients. In that study, cerebellar SS was associated with a higher number of supratentorial lobar and superficial cerebellar macrobleeds (although cerebellar SS was not directly located adjacent to these cerebellar macrobleeds). It is unclear if cerebellar SS is caused by in situ leakage of cerebellar leptomeningeal vessels or rather represents hemorrhagic diffusion from cerebellar parenchymal micro/macrobleeds or from supratentorial bleeding sources via the tentorium cerebelli (TC).

Study Type

OBSERVATIONAL

Enrollment

111

Conditions

Cerebral Amyloid Angiopathy Siderosis

Interventions

None, pure observational studyOTHER

None, pure observational study

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * CAA patients (according to the modified Boston criteria) * with acute symptoms related to acute ICH, acute subarachnoid haemorrhage, or cortical SS Exclusion Criteria: * Patients with recent trauma, * Patients with anticoagulation treatment, * Patients with pathological blood coagulation tests (activated partial thromboplastin time \[aPTT\] ratio=patient's aPTT/normal control aPTT\] \>1.2; or partial thromboplastin time \[PTT\] \<75%) or platelet count (\<100 x 109/L) * Patients with inflammatory CAA

Outcomes

Primary Outcomes

MRI analyse : presence of cerebellar SS

presence of cerebellar SS (Yes/No)

Time frame: baseline

MRI analyse : Location of cerebellar SS

Location of cerebellar SS (vermis, anterior lobe, posterior lobe)

Time frame: baseline

MRI analyse : characteristics of cerebellar SS

number of cerebellar sulci involved

Time frame: baseline

MRI analyse : characteristics of cerebellar SS

spatial relationship with cerebellar micro- and macrobleeds

Time frame: baseline

MRI analyse : Presence of cerebellar macrobleeds

Presence of cerebellar macrobleeds (Yes/No)

Time frame: baseline

MRI analyse : Presence of cerebral macrobleeds

Presence of cerebral macrobleeds (Yes/No)

Time frame: baseline

MRI analyse : Characteristics of cerebral macrobleeds

spatial relationship of cerebral macrobleeds with the TC \[adjacent vs. non-adjacent to TC\]

Time frame: baseline

MRI analyse : Characteristics of cortical SS

spatial relationship with TC (adjacent vs. non-adjacent to TC)

Time frame: baseline

MRI analyse : hemosiderin

presence of hemosiderin deposition along the TC.

Time frame: baseline

Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes