Intravascular Lithotripsy in Comparison to Rotational Atherectomy: An Evaluation by OFDI

Inclusion Criteria: 1. Patient ≥ 18 years old 2. Subjects with native coronary artery disease (including stable or unstable angina and silent ischemia) suitable for Percutaneous Coronary Intervention (PCI) 3. For patients with unstable ischemic heart disease, biomarkers (troponin or CK-MB) must be less than or equal to the upper limit of the lab (URL) normal within 12 hours prior to the procedure 4. The target lesion must be a de novo coronary lesion that has not been previously treated with any interventional procedure 5. Single de novo target lesion stenosis of protected LMCA, or LAD, RCA, or LCX (or of their branches) with: 1. Stenosis of ≥70% and \<100% 2. or Stenosis ≥50% and \<70% (visually assessed) with evidence of ischemia via positive stress test, or fractional flow reserve value ≤0.80 6. The target vessel reference diameter must be ≥2.5 mm and ≤4.0 mm 7. The lesion length must not exceed 40 mm 8. The target vessel must have TIMI flow 3 at baseline 9. Evidence of calcification at the lesion with a B or C Mintz classification site: B: Moderate calcification: radiopacities are noted only during the cardiac cycle before contrast injection C: severe calcification: radiopacities are seen without cardiac motion, also before contrast injection, usually affecting both sides of the arterial lumen. 10. Ability to pass a 0.014" guidewire across the lesion 11. Ability to cross target lesion with a 2 mm balloon 12. Patient insured under the French healthcare system ("Régime National Assurance Maladie") 13. Lesions in non-target vessels requiring PCI may be treated either: * a. \>30 days prior to the study procedure if the procedure was unsuccessful or complicated; or * b. \>24 hours prior to the study procedure if the procedure was successful and uncomplicated (defined as a final lesion angiographic diameter stenosis \<30% and TIMI 3 flow (visually assessed) for all non-target lesions and vessels without perforation, cardiac arrest or need for defibrillation or cardioversion or hypotension/heart failure requiring mechanical or intravenous hemodynamic support or intubation, and with no post-procedure biomarker elevation \>normal; or * c. \>30 days after the study procedure d. Could be treated in the same time of the diagnosis coronarography with respect of the delay for the index procedure of the protocol as described above 14. Patient able to assess and understand the risks and benefits, to accept and participate in the study (by signing an informed consent form and knowledgeable of the information letter). 15. Patient accepting the appropriate follow-up as per study definition Exclusion Criteria: 1. Patient age \< 18 years 2. The subject is pregnant or nursing 3. Patient refusing to participate in the study or unable to give informed consent (Guardianship, curatorship or judicial safeguard) 4. Any comorbidity or condition which may reduce compliance with this protocol, including follow-up visits 5. The protected subject according to the current legislation (articles L.1121-5 to L.1121-8 of the French Code of Public Health). 6. The subject is participating in another research study involving an investigational agent (pharmaceutical, biologic, or medical device), unless it is authorized by the concomitant study protocol. 7. Unable to tolerate dual antiplatelet therapy (i.e., aspirin, and either clopidogrel, prasugrel, or ticagrelor) for at least 6 months 8. The subject has an allergy to imaging contrast media which cannot be adequately pre-medicated 9. The subject experienced an acute MI (STEMI or non-STEMI) within 30 days prior to index procedure, defined as a clinical syndrome consistent with an acute coronary syndrome with troponin or CK-MB greater than 1 time the local laboratory's upper normal limit 10. New York Heart Association (NYHA) class III or IV heart failure 11. History of a stroke or Transient Ischemic Attack (TIA) within 6 months, or any prior intracranial hemorrhage 12. Active peptic ulcer or upper gastrointestinal (GI) bleeding within 6 months 13. Uncontrolled diabetes defined as an HbA1c \>10% 14. Subjects in cardiogenic shock 15. Subject has an active systemic infection on the day of the index procedure with either fever, leukocytosis or requiring intravenous antibiotics 16. Subjects with a life expectancy of less than 1 year 17. Non-coronary interventional or surgical structural heart procedures (e.g., TAVR, MitraClip, LAA, or PFO occlusion…) within 30 days prior to the index procedure 18. Planned non-coronary interventional or surgical structural heart procedures (e.g., TAVR, MitraClip, LAA or PFO occlusion...) 19. Subject refusing or not a candidate for emergency coronary artery bypass grafting (CABG) surgery 20. High SYNTAX Score (≥33) if assessed as a standard of care, unless the local heart team has met and recommends PCI is the most appropriate treatment for the patient 21. Definite or possible thrombus (by angiography or intravascular imaging) in the target vessel 22. Evidence of aneurysm in target vessel within 10 mm of the target Lesion 23. Unprotected left main 24. Target lesion is located in a native vessel that can only be reached by going through a saphenous vein or arterial bypass graft 25. Angiographic evidence of dissection in the target vessel at baseline or after guidewire passage 26. Ejection fraction less than 30 % evaluated in TTE, angiography or MRI 27. Patient suffering of lymphoma, leukemia and other malignancies 28. Patient suffering of liver disease