The aim of the study is to assess the clinical outcome in patients with Parkinson's disease treated with directional deep brain stimulation (dDBS). The patients have been selected for the dDBS treatment by their treating neurologist. The study is a registry-based follow-up study.
The study group consists of patients with advanced Parkinson's disease treated with directional deep brain stimulation in Helsinki University Hospital between 2017 - 2020. The study is a registry-based follow-up study. The aim of the study is to assess the clinical outcome and possible adverse effects of the dDBS treatment. The data will be collected from the patient records. The observed time points are 6-month's, 12-month's and 18-month's postoperative visits. The following data will collected: the scores of Unified Parkinson's disease questionnaire part III (UPDRS-III), Non-Motor Symptoms Questionnaire (NMS-quest), Beck Depression Inventory (BDI), Mini-Mental State Examination (MMSE), Abnormal Involuntary Movement Scale (AIMS) evaluated in the screening phase for dDBS treatment and at 6-months' follow-up. Possible levodopa equivalent dose changes, LEDDs, will also be assessed at these time points.
Study Type
OBSERVATIONAL
Enrollment
20
HUH Meilahti Hospital, department of neurology
Helsinki, Finland
The actual use of directional DBS stimulation in everyday life during the follow-up
The use of directionality in DBS in patients with PD in everyday life
Time frame: 6-18 months
The changes of UPDRS part III score during the DBS treatment
The changes of UPDRS part III score during the DBS treatment
Time frame: From the initiation of DBS treatment to 18-month's postoperative visit
Evaluation of the dDBS parameters
The use of dDBS, active contacts and the dDBS programming protocol will be studied.
Time frame: 6 months to 18 months
Possible adverse effects
Possible adverse effects of dDBS operation and treatment will be collected
Time frame: 6 months-18 months
LEDDs
Possible changes of levodopa equivalent doses, LEDDs, are studied
Time frame: From preoperative visit to 18 month's postoperative visit
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