HPI monitoring and the adoption of therapeutic interventions before hypotension occurs should be ensure a shorter time of intra-operative hypotension (MAP \< 65 mmHg) during deceased-donor kidney transplant surgery. The control group is represented by patients undergoing the same surgical procedure with hemodynamic monitoring with invasive blood pressure monitoring which represents the gold standard for this surgery. HPI monitoring has not yet been investigated during this surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
46
ACUMEN sensor generates HPI index which should predict hypotension. Based on HPI index, Eadyn and dP/dTmax values anaesthesia should somministrate liquid or drugs to prevent hypotension.
Invasive Blood Pressure permits continue monitoring of blood pressure (routine standard for kidney transplant surgery)
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy
RECRUITINGIntra-operative hypotension time
Hypotension (MAP \< 65 mmHg) time relative to the range from 20 minutes after induction to the end of surgery
Time frame: From 20 minutes after anaesthesia induction to the end of surgery (intra-operative)
Post-operative hypotension time
Hypotension (MAP \< 65 mmHg) time relative to the range from the end of surgery to the first 12 hours after surgery
Time frame: From the end of surgery to the first 12 hours after surgery (post-operative)
Intra-operative severe hypotension time
Severe hypotension (MAP \< 50 mmHg) time relative to the range from 20 minutes after induction to the end of surgery
Time frame: From 20 minutes after anaesthesia induction to the end of surgery (intra-operative)
Major Adverse Cardiovascular Events (MACE)
Number of major cardiovascular complications (MACE) within the first five days after kidney transplantation (for MACE the composite endpoint of heart attack is considered heart failure, heart failure or presumed cardiac death)
Time frame: First 5 post-operative days after surgery (post-operative)
Hospital mortality
Number of patient died in the first 30 days after surgery
Time frame: First 30 post-operative days after surgery (post-operative)
Intensive Care Unit Length of Stay
Number of hours of ICU admission
Time frame: First 30 post-operative days after surgery (post-operative)
Hospital Length of Stay
Number of days before hospital discharge
Time frame: First 30 post-operative days after surgery (post-operative)
Delayed Graft Function (DGF)
Need for hemodialysis in first 7 postoperative days
Time frame: First 7 post-operative days (post-operative)
Graft survival
Time frame: 30 days after transplantation
Post-operative delirium
CAM-ICU positive (asses one time for a day in the first 5 postoperative days)
Time frame: First 5 post-operative days
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